Novel activities of CYP11A1 and their potential physiological significance
Volume: 151, Pages: 25 - 37
Published: Jul 1, 2015
Abstract
CYP11A1, found only in vertebrates, catalyzes the first step of steroidogenesis where cholesterol is converted to pregnenolone. The purified enzyme, also converts desmosterol and plant sterols including campesterol and β-sitosterol, to pregnenolone. Studies, initially with purified enzyme, reveal that 7-dehydrocholesterol (7DHC), ergosterol, lumisterol 3, and vitamins D3 and D2 also serve as substrates for CYP11A1, with 7DHC being better and...
Paper Details
Title
Novel activities of CYP11A1 and their potential physiological significance
Published Date
Jul 1, 2015
Volume
151
Pages
25 - 37
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