The Journal of Steroid Biochemistry and Molecular Biology
Papers 6735
1 page of 674 pages (6,735 results)
#1Alzbeta Stefela (Charles University in Prague)
#2Miroslav Kaspar (Charles University in Prague)H-Index: 1
Last. Stanislav Micuda (Charles University in Prague)H-Index: 18
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Abstract Bile acids (BAs) are important signaling molecules acting via the farnesoid X nuclear receptor (FXR) and the membrane G protein-coupled bile acid receptor 1 (GPBAR1). Besides deconjugation of BAs, the oxidoreductive enzymes of colonic bacteria and hepatocytes enable the conversion of BAs into their epimers or dehydrogenated forms. Obeticholic acid (OCA) is the first-in-class BA-derived FXR agonist approved for the treatment of primary biliary cholangitis. Herein, a library of OCA deriva...
#1Elise Thoresen Sletten (UNN: University Hospital of North Norway)H-Index: 2
Last. Georg Sager (UNN: University Hospital of North Norway)H-Index: 21
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Abstract The classical steroid receptors (nuclear receptors), including those for progesterone (nPRs), are thoroughly characterized. The knowledge about so-called non-genomic effects, which are mediated by extra-nuclear initiated signals, has increased immensely the last decades. In a previous clinical study of endometrial hyperplasia, we observed that the antiproliferative progestin effect persisted after 3 months treatment with levonorgestrel (LNG) intrauterine system (IUS) even with a complet...
#1Peijie Wang (NWAFU: Northwest A&F University)H-Index: 1
#2Shujuan Liu (NWAFU: Northwest A&F University)
Last. Xiaopeng An (NWAFU: Northwest A&F University)H-Index: 9
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Abstract PTX3, a member of the pentraxin protein family, plays important roles in ovulation as a marker of cumulus cell–oocyte complex expansion. However, the expression and function of PTX3 in goat ovarian GCs remain unclear. We isolated GCs from small and large follicles and found that PTX3 expression was significantly decreased and miR-29 mRNA expression was significantly increased during the growth of antral follicles. MiR-29 decreased PTX3 expression by targeting its 3′ untranslated. Furthe...
#1Shenqiang Hu (Sichuan Agricultural University)H-Index: 6
#2Shanyan Gao (Sichuan Agricultural University)H-Index: 2
Last. Hehe Liu (Sichuan Agricultural University)H-Index: 10
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Abstract Accumulating evidence shows that granulosa cells within both mammalian and avian ovaries have the ability to synthesize fatty acids through de novo lipogenesis and to accumulate triglycerides essential for oocyte and ovarian development. However, very little is known about the exact roles of key genes involved in the lipid metabolic pathway in granulosa cells. The goal of this study was to investigate the differential actions of diacylglycerol acyltransferase (DGAT) 1 and 2, which are r...
#1Armina A. KaziH-Index: 12
#1Armina A. Kazi (UB: University of Baltimore)
Last. Gauri SabnisH-Index: 25
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Abstract Treatment of hormone sensitive breast cancer tumors with endocrine therapy such as antiestrogens or aromatase inhibitors has improved the outcome significantly. Studies including our own have shown that downregulation of ERα with pure antiestrogen fulvestrant in combination with aromatase inhibitors may prolong responsiveness of the tumors to endocrine therapy. Fulvestrant has been studied as second line or first line treatment for post-menopausal hormone receptor positive breast cancer...
Abstract Recent evidences suggest a protective mechanism of vitamin D signaling against breast cancer by the autocrine/paracrine manner and may modestly reduce the risk of breast cancer. Despite lots of sunshine, vitamin D deficiency is widespread in India. Moreover, there are limited studies from Indian population regarding circulatory 25(OH) D and breast cancer risk. Thus, the aim of the present study is to investigate circulatory 25(OH) D in relation to breast cancer risk and its association ...
#1Courtney Martin (LLU: Loma Linda University)H-Index: 2
#2Bryan T. Oshiro (LLU: Loma Linda University)H-Index: 8
Last. Eugenia Mata-Greenwood (LLU: Loma Linda University)H-Index: 16
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Abstract Vitamin D deficiency has been associated with preeclampsia, however, vitamin D supplementation studies have shown equivocal data on amelioration of this disease. We hypothesize that women with preeclampsia have an altered endogenous vitamin D homeostasis that counteracts the beneficial effects of vitamin D supplementation. Our study population consisted of 66 maternal/neonate dyads: 16 early-onset (
#1Sonja Sivcev (Charles University in Prague)H-Index: 1
#2Barbora SlavikovaH-Index: 9
Last. Hana ZemkovaH-Index: 21
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Abstract The family of ATP-gated purinergic P2X receptors comprises seven subunits (P2 × 1-7) that are unevenly distributed in the central and peripheral nervous systems as well as other organs. Endogenous modulators of P2X receptors are phospholipids, steroids and neurosteroids. Here, we analyzed whether bile acids, which are natural products derived from cholesterol, affect P2X receptor activity. We examined the effects of primary and secondary bile acids and newly synthesized derivatives of l...
#1Lise Barnard (Stellenbosch University)H-Index: 4
#2Nikolaos Nikolaou (University of Oxford)H-Index: 6
Last. Jeremy W. Tomlinson (University of Oxford)H-Index: 48
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Abstract Testosterone and its 5α-reduced form, 5α-dihydrotestosterone, were previously thought to represent the only active androgens in humans. However, recent studies have shown that the potent androgen, 11-ketotestosterone, derived from the adrenal androgen precursor, 11β-hydroxyandrostenedione, may in fact serve as the primary androgen in healthy women. Yet, despite recent renewed interest in these steroids, their downstream metabolism has remained undetermined. We therefore set out to inves...
#1Sudhaker D. Rao (HFHS: Henry Ford Health System)H-Index: 12
#2Joanna Miragaya (HFH: Henry Ford Hospital)
Last. George Divine (HFHS: Henry Ford Health System)H-Index: 41
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Abstract In patients with primary hyperparathyroidism, the size of the adenoma is a major determinant of biochemical indices, disease severity, and manner of presentation. However, the large variation in adenoma weight, both within and between populations and a steady decline in parathyroid adenoma weights over time remain largely unexplained. Based on the results in a small number of patients almost two decades ago we proposed that vitamin D nutritional status of the patient explains both the d...
Top fields of study
Estrogen receptor