From Prader–Willi syndrome to psychosis: translating parent-of-origin effects into schizophrenia research
Abstract
Prader-Willi syndrome (PWS) is a relatively rare disorder that originates from paternally inherited deletions and maternal disomy (mUPD) within the 15q11-q13 region or alterations in the PWS imprinting center. Evidence is accumulating that mUPD underlies high prevalence of psychosis among PWS patients. Several genes involved in differentiation and survival of neurons as well as neurotransmission known to act in the development of PWS have been...
Paper Details
Title
From Prader–Willi syndrome to psychosis: translating parent-of-origin effects into schizophrenia research
Published Date
Dec 1, 2014
Journal
Volume
6
Issue
6
Pages
677 - 688
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