Interactions between the −514C→T polymorphism of the hepatic lipase gene and lifestyle factors in relation to HDL concentrations among US diabetic men

Low plasma HDL-cholesterol concentrations are a hallmark of diabetic dyslipidemia. A common polymorphism (−514C→T) of the hepatic lipase gene (LIPC), which accounts for up to 30% of the variation in hepatic lipase activity, has been associated with low hepatic lipase activity and high HDL-cholesterol concentrations. We examined the association between this polymorphism and plasma HDL-cholesterol concentrations and evaluated whether this...