Original paper
Preparation, antitumor activity in mice, pharmacokinetics and tissue distribution in rats of di-n-butyl-di-(4-chlorobenzohydroxamato)tin(IV) liposome
Abstract
Di‐n‐butyl‐di‐(4‐chlorobenzohydroxamato)tin(IV) (DBDCT) is an antitumor compound with high activity and relatively low bioavailability. In order to improve the pharmacokinetic characteristics and raise its therapeutic index, a liposome of DBDCT (DBDCT‐L) was prepared for the first time. A study of the pharmacokinetics and tissue distribution after intravenous administration of DBDCT‐L compared with free DBDCT to rats was investigated. DBDCT‐L...
Paper Details
Title
Preparation, antitumor activity in mice, pharmacokinetics and tissue distribution in rats of di-n-butyl-di-(4-chlorobenzohydroxamato)tin(IV) liposome
Published Date
Jan 21, 2014
Volume
28
Issue
3
Pages
204 - 210
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Notes
History