Review paper
Preventing the transmission of mitochondrial DNA disorders using prenatal or preimplantation genetic diagnosis
Volume: 1350, Issue: 1, Pages: 29 - 36
Published: Aug 27, 2015
Abstract
Mitochondrial disorders are among the most common inborn errors of metabolism; at least 15% are caused by mitochondrial DNA (mtDNA) mutations, which occur de novo or are maternally inherited. For familial heteroplasmic mtDNA mutations, the mitochondrial bottleneck defines the mtDNA mutation load in offspring, with an often high or unpredictable recurrence risk. Oocyte donation is a safe option to prevent the transmission of mtDNA disease, but...
Paper Details
Title
Preventing the transmission of mitochondrial DNA disorders using prenatal or preimplantation genetic diagnosis
Published Date
Aug 27, 2015
Volume
1350
Issue
1
Pages
29 - 36
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