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Annals of the New York Academy of Sciences
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#1Steve PaulsonH-Index: 3
#2Marcelo Gleiser (Dartmouth College)H-Index: 26
Last. Gavin Francis (Royal College of Physicians of Edinburgh)
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Einstein famously claimed that "the most incomprehensible thing about the universe is that it is comprehensible." This statement suggests that no amount of scientific explanation will suffice to make sense of the bizarre situation of the human mind within the universe. So what are the actual roles of awe and wonder within the framework of contemporary science? How, for instance, do awe and wonder inform scientists' understanding of the phenomena they are researching? What aspects of contemporary...
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#1Steve PaulsonH-Index: 3
#2Michelle “Lani” Shiota (ASU: Arizona State University)
Last. Alexei V. Filippenko (University of California, Berkeley)H-Index: 118
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From the macrocosm of the universe to the microcosm of the human body, our discoveries about ourselves and the natural world continue to spark our experience of awe and wonder. But how exactly does science define and explain the experience of awe and wonder? Social psychologist Michelle Shiota, writer Caspar Henderson, and astrophysicist Alex Filippenko unpack the emerging science behind the emotions of awe and wonder, including their role in our ongoing quest for understanding and knowledge.
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#1Steve PaulsonH-Index: 3
#2Lisa H. SiderisH-Index: 4
Last. Piercarlo Valdesolo (CMC: Claremont McKenna College)H-Index: 11
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Awe and wonder appear to be powerful emotions that can inform and shape our attitudes toward ourselves and others, especially in relation to the larger meaning and purpose of our lives. What are the psychological underpinnings of these universal emotions? How does awe, for example, relate to self-knowledge, and more generally to understanding the enigmatic contradictions of human nature? Is it possible to cultivate and develop this emotion as an ethical incentive in our relationships with others...
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#1Zhongqiang Li (LSU: Louisiana State University)H-Index: 1
#2Yoshita V. Holamoge (LSU: Louisiana State University)
Last. Jian Xu (LSU: Louisiana State University)H-Index: 9
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Cracked teeth are the third most common cause of tooth loss, but there is no reliable imaging tool for the diagnosis of cracks. Here, we demonstrate the feasibility of indocyanine green near-infrared fluorescence (ICG-NIRF) dental imaging for the detection of enamel cracks and enamel-dentin cracks in vitro in the first (ICG-NIRF-I, 700-950 nm) and second (ICG-NIRF-II, 950-1700 nm) imaging windows with transmission excitation light, and compared ICG-NIRF with conventional NIR illumination-II (NIR...
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#2Yubao Gong (Albert Einstein College of Medicine)
Last. Hui B. Sun (Albert Einstein College of Medicine)H-Index: 17
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Tendinopathy is a common musculoskeletal disorder characterized by chronic low-grade inflammation and tissue degeneration. Tendons have poor innate healing ability and there is currently no cure for tendinopathy. Studies elucidating mechanisms underlying the pathogenesis of tendinopathy and mechanisms mediating the genesis of tendons during development have provided novel targets and strategies to enhance tendon healing and repair. This review summarizes the current understanding and treatments ...
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#1Sarah E. Diamond (Case Western Reserve University)H-Index: 22
#2Ryan A. Martin (Case Western Reserve University)H-Index: 16
Although there is considerable optimism surrounding adaptive evolutionary responses to global change, relatively little attention has been paid to maladaptation in this context. In this review, we consider how global change might lead populations to become maladapted. We further consider how populations can evolve to new optima, fail to evolve and therefore remain maladapted, or become further maladapted through trait-driven or eco-evo-driven mechanisms after being displaced from their fitness o...
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#1Chi Him Poon (Li Ka Shing Faculty of Medicine, University of Hong Kong)
#2Long Sum Rachel Tse (Li Ka Shing Faculty of Medicine, University of Hong Kong)
Last. Lee Wei Lim (Li Ka Shing Faculty of Medicine, University of Hong Kong)
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Alzheimer's disease (AD) is a debilitating disorder that manifests with amyloid beta plaque deposition, neurofibrillary tangles, neuronal loss, and severe cognitive impairment. Although much effort has been made to decipher the pathogenesis of this disease, the mechanisms causing these detrimental outcomes remain obscure. Over the past few decades, neuroepigenetics has emerged as an important field that, among other things, explores how reversible modifications can change gene expression to cont...
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#1Min Liao (CAU: China Agricultural University)H-Index: 1
#2Qibo Li (CAU: China Agricultural University)H-Index: 2
Last. Shangzhong Liu (CAU: China Agricultural University)H-Index: 8
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There is a significant need to study the binding of active compounds to the specific sites on insect ryanodine receptors (RyRs) that are the targets of two novel classes of diamide insecticides to which insects are becoming increasingly resistant. Here, we describe a rapid assay to study the action of potential compounds on the flubendiamide (Flu) binding site of insect RyRs that uses a fluorescence polarization assay with the fluorescence probe Flu-R-L that we synthesized. The IC50 of Flu for i...
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#1Jia-Yu Zhong (CSU: Central South University)H-Index: 1
#2Xing-Jun Cui (CSU: Central South University)H-Index: 2
Last. You-Shuo Liu (CSU: Central South University)H-Index: 8
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Long noncoding RNAs (lncRNAs) have been investigated as novel regulatory molecules involved in diverse biological processes. Our previous study demonstrated that lncRNA-ES3 is associated with the high glucose-induced calcification/senescence of human aortic vascular smooth muscle cells (HA-VSMCs). However, the mechanism of lncRNA-ES3 in vascular calcification/aging remained largely unknown. Here, we report that the expression of basic helix-loop-helix family member e40 (Bhlhe40) was decreased si...
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#1Junxiong Zhu (PKU: Peking University)H-Index: 1
#2Can Liu (PKU: Peking University)H-Index: 3
Last. Chunli Song (PKU: Peking University)H-Index: 7
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Caloric restriction (CR) is well described and has received extensive attention for its multiple benefits, including longevity and stress resistance. However, some studies have shown that CR negatively influences bone, although a mechanism hasn't been provided. Adiponectin, an adipocyte-derived hormone, can affect bone metabolism by various pathways. To explore the role of adiponectin in short-term CR on bone, we tested the effect of short-term CR on limb bones (tibia and femur) and lumbar verte...
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