Effect of active Aβ immunotherapy on neurons in human Alzheimer's disease

Amyloid β peptide (A β ) immunization of Alzheimer's disease ( AD ) patients has been reported to induce amyloid plaque removal, but with little impact on cognitive decline. We have explored the consequences of A β immunotherapy on neurons in post mortem brain tissue. Eleven immunized ( AN1792 , Elan Pharmaceuticals) AD patients were compared to 28 non‐immunized AD cases. Immunohistochemistry on sections of neocortex was performed for...