Virgin coconut oil maintains redox status and improves glycemic conditions in high fructose fed rats

Published on Jan 1, 2016in Journal of Food Science and Technology-mysore1.85
· DOI :10.1007/s13197-015-2040-8
Arunaksharan Narayanankutty6
Estimated H-index: 6
(University of Calicut),
Reshma K. Mukesh1
Estimated H-index: 1
(University of Calicut)
+ 5 AuthorsAchuthan C. Raghavamenon5
Estimated H-index: 5
(University of Calicut)
Virgin Coconut Oil (VCO), extracted from fresh coconut kernel possess similar fatty acid composition to that of Copra Oil (CO), a product of dried kernel. Although CO forms the predominant dietary constituent in south India, VCO is being promoted for healthy life due to its constituent antioxidant molecules. High fructose containing CO is an established model for insulin resistance and steatohepatitis in rodents. In this study, replacement of CO with VCO in high fructose diet markedly improved the glucose metabolism and dyslipidemia. The animals fed VCO diet had only 17 % increase in blood glucose level compared to CO fed animals (46 %). Increased level of GSH and antioxidant enzyme activities in VCO fed rats indicate improved hepatic redox status. Reduced lipid peroxidation and carbonyl adducts in VCO fed rats well corroborate with the histopathological findings that hepatic damage and steatosis were comparatively reduced than the CO fed animals. These results suggest that VCO could be an efficient nutraceutical in preventing the development of diet induced insulin resistance and associated complications possibly through its antioxidant efficacy.
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#1Prem Prakash (Central Drug Research Institute)H-Index: 12
#2Vishal Singh (Central Drug Research Institute)H-Index: 16
Last.Madhu Dikshit (Central Drug Research Institute)H-Index: 33
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Cited By19
#1Ali Osman (Zagazig University)H-Index: 9
#1Marina Campos Zicker (UFMG: Universidade Federal de Minas Gerais)H-Index: 2
#2Ana Letícia Malheiros Silveira (UFMG: Universidade Federal de Minas Gerais)H-Index: 3
Last.Adaliene Versiani Matos Ferreira (UFMG: Universidade Federal de Minas Gerais)H-Index: 12
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