Soluble CD40 ligand (sCD40L) provides a new delivery system for targeted treatment

BACKGROUND: A wide range of hematologic malignancies arises from numerous cell types. In an attempt to offer a new target for treating B‐cell malignancies, in this study, the authors tested the possibility of using the CD40/CD40L system as a common targeting system for the various malignancies in this group. METHODS: Two chimeric proteins, soluble CD40 ligand (sCD40L)‐caspase 3 (sCD40L‐l‐Caspase3) and sCD40L‐pseudomonas exotoxin 38 (PE38)...