Review paper
Metabolic reprogramming in macrophages and dendritic cells in innate immunity
Abstract
Activation of macrophages and dendritic cells (DCs) by pro-inflammatory stimuli causes them to undergo a metabolic switch towards glycolysis and away from oxidative phosphorylation (OXPHOS), similar to the Warburg effect in tumors. However, it is only recently that the mechanisms responsible for this metabolic reprogramming have been elucidated in more detail. The transcription factor hypoxia-inducible factor-1α (HIF-1α) plays an important role...
Paper Details
Title
Metabolic reprogramming in macrophages and dendritic cells in innate immunity
Published Date
Jun 5, 2015
Journal
Volume
25
Issue
7
Pages
771 - 784
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History