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Cell Research
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17.85
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2975
Papers 2981
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Multisystem manifestations in myotonic dystrophy type 1 (DM1) may be due to dosage reduction in multiple genes induced by aberrant expansion of CTG repeats in DMPK, including DMPK, its neighboring genes (SIX5 or DMWD) and downstream MBNL1. However, direct evidence is lacking. Here, we develop a new strategy to generate mice carrying multigene heterozygous mutations to mimic dosage reduction in one step by injection of haploid embryonic stem cells with mutant Dmpk, Six5 and Mbnl1 into oocytes. Th...
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Coagulation balance is maintained through fine-tuned interactions among clotting factors, whose physiological concentrations vary substantially. In particular, the concentrations of coagulation proteases (pM to nM) are much lower than their natural inactivator antithrombin (AT, ~ 3 μM), suggesting the existence of other coordinators. In the current study, we found that transferrin (normal plasma concentration ~40 μM) interacts with fibrinogen, thrombin, factor XIIa (FXIIa), and AT with different...
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Metastasis, the development of secondary malignant growths at a distance from a primary tumor, is the cause of death for 90% of cancer patients, but little is known about how metastatic cancer cells adapt to and colonize new tissue environments. Here, using clinical samples, patient-derived xenograft (PDX) samples, PDX cells, and primary/metastatic cell lines, we discovered that liver metastatic colorectal cancer (CRC) cells lose their colon-specific gene transcription program yet gain a liver-s...
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#1Zhangyuan Yin (UM: University of Michigan)H-Index: 2
#2Xu Liu (UM: University of Michigan)H-Index: 11
Last.Daniel J. Klionsky (UM: University of Michigan)H-Index: 113
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Macroautophagy/autophagy defines an evolutionarily conserved catabolic process that targets cytoplasmic components for lysosomal degradation. The process of autophagy from initiation to closure is tightly executed and controlled by the concerted action of autophagy-related (Atg) proteins. Although substantial progress has been made in characterizing transcriptional and post-translational regulation of ATG/Atg genes/proteins, little is known about the translational control of autophagy. Here we r...
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#1Daniel Fox (ANU: Australian National University)H-Index: 2
#2Si Ming Man (ANU: Australian National University)H-Index: 29
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#1Lingjun Zheng (Fujian Agriculture and Forestry University)H-Index: 1
#2Xiaoqi Wu (Fujian Agriculture and Forestry University)H-Index: 1
Last.Ding Xue (CU: University of Colorado Boulder)H-Index: 35
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Molecular biology
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