Luke A. J. O'Neill
Trinity College, Dublin
ReceptorImmunologySignal transductionBiologyCell biology
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Publications 503
#1Zbigniew Zasłona (Trinity College, Dublin)H-Index: 9
#2Luke A. J. O'Neill (Trinity College, Dublin)H-Index: 106
Metabolites have functions in the immune system independent of their conventional roles as sources or intermediates in biosynthesis and bioenergetics. We are still in the pioneering phase of gathering information about the functions of specific metabolites in immunoregulation. In this review, we cover succinate, itaconate, alpha-ketoglutarate, and lactate as examples. Each of these metabolites has a different story of how their immunoregulatory functions were discovered and how their roles in th...
1 CitationsSource
#1Marah C Runtsch (Trinity College, Dublin)H-Index: 2
#2Luke A. J. O'Neill (Trinity College, Dublin)H-Index: 106
Itaconate is an immunometabolite with anti-inflammatory and anti-microbial properties. Riquelme et al. (2020) demonstrate that pathogenic Pseudomonas aeruginosa drives itaconate production by macrophages, which it then uses as a carbon source for biofilm formation, allowing it to persist during infection and suppress inflammation.
#1Michael P. Murphy (University of Cambridge)H-Index: 98
#2Luke A. J. O'Neill (Trinity College, Dublin)H-Index: 106
Immunologists used to avoid metabolism, but that is no longer possible. Now that we must talk about it, how can we do so in a way that enhances and clarifies our understanding of the role metabolism plays in the immune response?
1 CitationsSource
#1James J. Phelan (Trinity College, Dublin)H-Index: 5
#2Kate McQuaid (Trinity College, Dublin)
Last. Mary P. O'Sullivan (Trinity College, Dublin)H-Index: 17
view all 13 authors...
Tuberculosis is the single biggest infectious killer in the world and presents a major global health challenge. Antimicrobial therapy requires many months of multiple drugs and incidences of drug resistant tuberculosis continues to rise. Consequently, research is now focused on the development of therapies to support the function of infected immune cells. HIF1α-mediated induction of aerobic glycolysis is integral to the host macrophage response during infection with Mtb, as this promotes bacilla...
#1Luke A. J. O'Neill (Trinity College, Dublin)H-Index: 106
#2Mihai G. Netea (University of Bonn)H-Index: 1
Bacillus Calmette–Guerin (BCG) vaccination has been reported to decrease susceptibility to respiratory tract infections, an effect proposed to be mediated by the general long-term boosting of innate immune mechanisms, also termed trained immunity. Here, we discuss the non-specific beneficial effects of BCG against viral infections and whether this vaccine may afford protection to COVID-19. Could the BCG vaccine be used to bridge the gap until a specific COVID-19 vaccine is developed? Luke O’Neil...
6 CitationsSource
#1Eunice E. To (Monash University, Clayton campus)H-Index: 2
#1Eunice To (RMIT: RMIT University)
Last. Stavros Selemidis (RMIT: RMIT University)H-Index: 23
view all 9 authors...
Significance: Reactive oxygen species (ROS) are often considered to be undesirable toxic molecules that are generated under conditions of cellular stress, which can cause damage to critical macromolecules such as DNA. However, ROS can also contribute to the pathogenesis of cancer and many other chronic inflammatory disease conditions, including atherosclerosis, metabolic disease, chronic obstructive pulmonary disease, neurodegenerative disease, and autoimmune disease. Recent Advances: The field ...
#1Eva M. Palsson-McDermott (Trinity College, Dublin)H-Index: 20
#2Luke A. J. O'Neill (Trinity College, Dublin)H-Index: 106
The growing field of immunometabolism has taught us how metabolic cellular reactions and processes not only provide a means to generate ATP and biosynthetic precursors, but are also a way of controlling immunity and inflammation. Metabolic reprogramming of immune cells is essential for both inflammatory as well as anti-inflammatory responses. Four anti-inflammatory therapies, DMF, Metformin, Methotrexate and Rapamycin all work by affecting metabolism and/or regulating or mimicking endogenous met...
2 CitationsSource
#1Zbigniew Zasłona (Trinity College, Dublin)H-Index: 9
#2Ewelina Flis (Trinity College, Dublin)H-Index: 2
Last. Alexander Hooftman (Trinity College, Dublin)H-Index: 1
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Activated caspase-1 and caspase-11 induce inflammatory cell death in a process termed pyroptosis. Here we show that Prostaglandin E2 (PGE2) inhibits caspase-11-dependent pyroptosis in murine and human macrophages. PGE2 suppreses caspase-11 expression in murine and human macrophages and in the airways of mice with allergic inflammation. Remarkably, caspase-11-deficient mice are strongly resistant to developing experimental allergic airway inflammation, where PGE2 is known to be protective. Expres...
1 CitationsSource
#1Stefano Angiari (Trinity College, Dublin)H-Index: 3
#2Marah C Runtsch (Trinity College, Dublin)H-Index: 2
Last. Luke A. J. O'Neill (Trinity College, Dublin)H-Index: 106
view all 11 authors...
Summary Pyruvate kinase (PK) catalyzes the conversion of phosphoenolpyruvate to pyruvate during glycolysis. The PK isoform PKM2 has additional roles in regulation of gene transcription and protein phosphorylation. PKM2 has been shown to control macrophage metabolic remodeling in inflammation, but its role in T cell biology is poorly understood. Here, we report PKM2 upregulation, phosphorylation, and nuclear accumulation in murine and human CD4+ T cells following activation in vitro. Treatment of...
6 CitationsSource
#1Dylan G. Ryan (Trinity College, Dublin)H-Index: 7
#2Luke A. J. O'Neill (Trinity College, Dublin)H-Index: 106
A striking change has happened in the field of immunology whereby specific metabolic processes have been shown to be a critical determinant of immune cell activation. Multiple immune receptor types...
6 CitationsSource