Hypoxia as a target for drug combination therapy of liver cancer
Abstract
Hepatocellular carcinoma (HCC) is the third most frequent cause of cancer deaths worldwide. The standard of care for intermediate HCC is transarterial chemoembolization, which combines tumour embolization with locoregional delivery of the chemotherapeutic doxorubicin. Embolization therapies induce hypoxia, leading to the escape and proliferation of hypoxia-adapted cancer cells. The transcription factor that orchestrates responses to hypoxia is...
Paper Details
Title
Hypoxia as a target for drug combination therapy of liver cancer
Published Date
Aug 1, 2017
Journal
Volume
28
Issue
7
Pages
771 - 780
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