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Schizophrenia Research
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Papers 19260
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#1Thomas Vaessen (Katholieke Universiteit Leuven)H-Index: 6
#2Wolfgang Viechtbauer (UM: Maastricht University)H-Index: 37
Last.Inez Myin-Germeys (Katholieke Universiteit Leuven)H-Index: 63
view all 21 authors...
Abstract Initial affective and psychotic reactivity to daily stressors is altered in psychosis, and most notably in early psychosis. In addition to altered initial stress reactivity, results from studies using Experience Sampling Methodology (ESM) and psychophysiological measures indicate that impaired recovery from mild stressors may also be a risk factor for mental illness. The current ESM study investigated affective recovery from daily stressors in chronic psychosis patients (CP; n = 162), i...
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#1Monica Aas (Oslo University Hospital)H-Index: 9
#2Diego A. Pizzagalli (Harvard University)H-Index: 60
Last.Ole A. Andreassen (Oslo University Hospital)H-Index: 89
view all 9 authors...
Abstract Background The neural diathesis-stress model is useful to understand schizophrenia (SZ) and bipolar (BD) disorders. Childhood maltreatment could affect the Hypothalamic–Pituitary–Adrenal (HPA)-axis and lead to chronic changes in stress-sensitivity, which can be measured with hair cortisol concentrations (HCC), representing long-term, cumulative cortisol levels. Here we investigated if childhood trauma experiences are associated with chronic changes in the HPA axis in severe mental disor...
1 CitationsSource
#1Felipe V. Gomes (University of Pittsburgh)H-Index: 19
#2Xiyu Zhu (University of Pittsburgh)H-Index: 3
Last.Anthony A. Grace (University of Pittsburgh)H-Index: 90
view all 3 authors...
Abstract Schizophrenia is a neurodevelopmental disorder with genetic predisposition, and stress has long been linked to its etiology. While stress affects all stages of the illness, increasing evidence suggests that stress during critical periods of development may be particularly detrimental, increasing individual's vulnerability to psychosis. To thoroughly understand the potential causative role of stress, our group has been focusing on the prenatal methylazoxymethanol acetate (MAM) rodent mod...
3 CitationsSource
#1Jan-Harry Cabungcal (UNIL: University of Lausanne)H-Index: 14
#2Pascal Steullet (UNIL: University of Lausanne)H-Index: 17
Last.Kim Q. Do (UNIL: University of Lausanne)H-Index: 46
view all 5 authors...
Abstract The fast-spiking parvalbumin (PV) interneurons play a critical role in neural circuit activity and dysfunction of these cells has been implicated in the cognitive deficits typically observed in schizophrenia patients. Due to the high metabolic demands of PV neurons, they are particularly susceptible to oxidative stress. Given the extant literature exploring the pathological effects of oxidative stress on PV cells in cortical regions linked to schizophrenia, we decided to investigate whe...
1 CitationsSource
#1Tyler S. Saunders ('KCL': King's College London)
#2Valeria Mondelli ('KCL': King's College London)H-Index: 36
Last.Alexis E. Cullen ('KCL': King's College London)H-Index: 13
view all 3 authors...
Abstract Background Pituitary volume (PV) abnormalities, representing one of several markers of hypothalamic-pituitary-adrenal (HPA) axis dysregulation, have been observed in psychosis, with variable patterns across illness stages. Typically, enlargements characterise first-episode patients, with reductions observed in those with chronic illness relative to healthy controls. Findings in high-risk populations have been inconsistent, highlighting the need for an updated review of the evidence. Met...
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#1Kirsten Cherian (Palo Alto University)H-Index: 1
#2Alan F. Schatzberg (Stanford University)H-Index: 89
Last.Jennifer Keller (Stanford University)H-Index: 23
view all 3 authors...
Abstract The Hypothalamic Pituitary Adrenal (HPA) axis has been implicated in the pathophysiology of a variety of mood and cognitive disorders. Neuroendocrine studies have demonstrated HPA axis overactivity in major depression, a relationship of HPA axis activity to cognitive performance, and a potential role of HPA axis genetic variation in cognition. In schizophrenia differential HPA activity has been found, including higher rates of non-suppression to dexamethasone challenge and higher saliva...
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#1Lauren M. Ellman (TU: Temple University)H-Index: 17
#2Shannon K. Murphy (TU: Temple University)H-Index: 4
Last.Alan S. Brown (Columbia University)H-Index: 44
view all 9 authors...
Abstract Introduction Maternal stress during pregnancy has been repeatedly linked to increased risk for schizophrenia; however, no study has examined maternal cortisol during pregnancy and risk for the disorder. Study aims were to determine whether prenatal cortisol was associated with risk for schizophrenia and risk for an intermediate phenotype—decreased fetal growth—previously linked to prenatal cortisol and schizophrenia. Timing of exposure and fetal sex also were examined given previous fin...
1 CitationsSource
#1Cynthia H. Lee (UNSW: University of New South Wales)
#2Duncan Sinclair (UTAS: University of Tasmania)H-Index: 2
Last.Thomas W. Weickert (State University of New York Upstate Medical University)H-Index: 31
view all 7 authors...
Abstract Altered levels of stress-signalling transcripts have been identified in post-mortem brains of people with schizophrenia, and since stress effects may be expressed throughout the body, there should be similar changes in peripheral cells. However, the extent to which these markers are altered in peripheral white blood cells of people with schizophrenia is not known. Furthermore, how peripheral cortisol and stress-related mRNA are associated with negative symptom severity and emotional sta...
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#1Christin Schifani (CAMH: Centre for Addiction and Mental Health)H-Index: 2
#2Sina Hafizi (CAMH: Centre for Addiction and Mental Health)H-Index: 10
Last.Romina MizrahiH-Index: 36
view all 9 authors...
Abstract Prolonged stress can cause neuronal loss in the hippocampus resulting in disinhibition of glutamatergic neurons proposed to enhance dopaminergic firing in subcortical regions including striatal areas. Supporting this, imaging studies show increased striatal dopamine release in response to psychosocial stress in healthy individuals with low childhood maternal care, individuals at clinical high risk for psychosis (CHR) and patients with schizophrenia. The prefrontal cortex (PFC) is connec...
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#1Allison M. LoPilato (Emory University)H-Index: 1
#2Katrina B. Goines (Emory University)H-Index: 3
Last.Elaine F. Walker (Emory University)H-Index: 61
view all 14 authors...
Abstract Childhood adversity is among the strongest risk factors for psychosis-spectrum disorders, though the nature and specificity of the biological mechanisms underlying this association remains unclear. Previous research reveals overlaps in the volumetric alterations observed in both adversity-exposed individuals and in psychosis-spectrum populations, highlighting the possibility that deviations in corticolimbic gray matter development may be one mechanism linking adversity and psychosis. Gi...
1 CitationsSource
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Top fields of study
Psychiatry
Developmental psychology
Psychology
Psychosis
Schizophrenia