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Schizophrenia Research
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#1Jonathan G. Leung (Mayo Clinic)H-Index: 11
#2Terri S. Wittenberger (Mayo Clinic)
Last. Kathryn M. Schak (Mayo Clinic)H-Index: 9
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#1Lyn Ellett (RHUL: Royal Holloway, University of London)H-Index: 10
#2Eryna Tarant (Surrey and Borders Partnership NHS Foundation Trust)
Last. Paul Chadwick (University of Bath)H-Index: 25
view all 7 authors...
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#1San-Ping Wang (NCKU: National Cheng Kung University)
#2Jung-Der Wang (NCKU: National Cheng Kung University)H-Index: 47
Last. Tso-Jen Wang (South Korean Ministry for Health, Welfare and Family Affairs)
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Abstract Objectives Employment status is considered a crucial predictor of improved functioning for patients with psychotic disorders. Frailty affects not only physical well-being but also employment outcomes, but few studies have explored the association between frailty and employment outcomes in patients with schizophrenia. This study is a longitudinal follow-up study that aimed to determine whether frailty is associated with employment outcomes in schizophrenia. Methods All 561 stable patient...
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#1Scott W. Woods (Yale University)H-Index: 77
#2Carrie E. Bearden (Semel Institute for Neuroscience and Human Behavior)H-Index: 59
Last. Albert R. Powers (Yale University)H-Index: 10
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Abstract Background Malhi et al. in this issue critique the clinical high risk (CHR) syndrome for psychosis. Method Response to points of critique. Results We agree that inconsistency in CHR nomenclature should be minimized. We respectfully disagree on other points. In our view: a) individuals with CHR and their families need help, using existing interventions, even though we do not yet fully understand disease mechanisms; b) substantial progress has been made in identification of biomarkers; c)...
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#1Veena Kumari (Brunel University London)H-Index: 60
#2Ulrich Ettinger (University of Bonn)H-Index: 41
Abstract In recent years there has been a surge of interest and corresponding accumulation of knowledge about the role of sleep disturbance in schizophrenia. In this review, we provide an update on the current status of experimentally controlled sleep deprivation (SD) as an experimental medicine model of psychosis, and also consider, given the complexity and heterogeneity of schizophrenia, whether this (state) model can be usefully combined with other state or trait model systems to more powerfu...
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Abstract Delusional topics tend to rapidly incorporate popular hot topical issues. Thus, the current coronavirus COVID-19 pandemic has rapidly reached delusional themes in patients with psychiatric disorders. Here we present the clinical case of a Spanish woman with bipolar disorder that included coronavirus infection in her delusional themes even faster than the real infection reached mainland Spain.
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#1Matthias Pillny (UHH: University of Hamburg)H-Index: 3
#2Björn Schlier (UHH: University of Hamburg)H-Index: 8
Last. Tania M. Lincoln (UHH: University of Hamburg)H-Index: 31
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Abstract Anticipatory pleasure refers to a state of positive affect in anticipation of future events that has been found to motivate goal-directed behavior. Previous research has indicated that patients with negative symptoms of psychosis show reduced goal-directed behavior because ‘demotivating beliefs’ impede anticipatory pleasure. This study aims to link demotivating beliefs and anticipatory pleasure to patients' motivation in everyday life. Using the Experience Sampling Method, we examined t...
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#1Jessica M. Gannon (University of Pittsburgh)H-Index: 4
Last. K. N. Roy Chengappa (University of Pittsburgh)H-Index: 26
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Abstract Background Schizophrenia is a complex disorder in which the causal relations between risk genes and observed clinical symptoms are not well understood and the explanatory gap is too wide to be clarified without considering an intermediary level. Thus, we aimed to test the hypothesis of a pathway from molecular polygenic influence to clinical presentation occurring via deficits in reinforcement learning. Methods We administered a reinforcement learning task (Go/NoGo) that measures reinfo...
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