Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor
Abstract
Expression of the colony-stimulating factor 1 (CSF1) gene is elevated in most tenosynovial giant-cell tumors. This observation has led to the discovery and clinical development of therapy targeting the CSF1 receptor (CSF1R).Using x-ray co-crystallography to guide our drug-discovery research, we generated a potent, selective CSF1R inhibitor, PLX3397, that traps the kinase in the autoinhibited conformation. We then conducted a multicenter, phase 1...
Paper Details
Title
Structure-Guided Blockade of CSF1R Kinase in Tenosynovial Giant-Cell Tumor
Published Date
Jul 29, 2015
Volume
373
Issue
5
Pages
428 - 437
Citation AnalysisPro
You’ll need to upgrade your plan to Pro
Looking to understand the true influence of a researcher’s work across journals & affiliations?
- Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
- Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.
Notes
History