Platelet activation markers overexpressed specifically in patients with aspirin-exacerbated respiratory disease

BackgroundAspirin-exacerbated respiratory disease (AERD) is characterized by respiratory reactions on ingestion of COX-1 inhibitors and cysteinyl leukotriene overproduction. The hypersensitivity reaction is induced by low doses of aspirin that inhibit COX-1 in platelets.ObjectiveWe sought to explore the role of platelets in the pathogenesis of AERD in patients under stable conditions and during an aspirin challenge test.MethodsStable patients...