Original paper
Severe Hypocalcemia in a Young Female During Postpartum Period: A Challenging Diagnosis of Primary Hypoparathyroidism
Abstract
Tarih Hypocalcemia is a clinical symptom of hypoparathyroidism, which is usually accompanied by distinctive signs and symptoms that vary depending on how severe and chronic the disease becomes. The aim of this study is to report on a case of severe hypocalcemia secondary to hypoparathyroidism in a postpartum woman. We present a case of a young woman with complaints of cramping legs and feet, tingling or burning in fingertips, toes, and lips,...
Figures & Tables
Figure 1. (A) Right foot oblique graph shows that 5th metatarsal proximal and di...
Paper Details
Title
Severe Hypocalcemia in a Young Female During Postpartum Period: A Challenging Diagnosis of Primary Hypoparathyroidism
Published Date
Jun 4, 2022
Journal
References6
Original paper
# 1Karen K. Winer(NIH: National Institutes of Health)
35
# 2Chia W. Ko(NIDCD: National Institute on Deafness and Other Communication Disorders)
9
Last. Gordon B. Cutler(NIH: National Institutes of Health)
79
Hypoparathyroidism is one of the few remaining hormonal insufficiency states for which replacement therapy is unavailable. Previous short-term controlled trials have shown PTH to be a safe and effective treatment of hypoparathyroidism. In this randomized, parallel group, open-label trial, we compared synthetic human PTH-(1-34) (PTH) with conventional therapy, calcitriol and calcium, over a 3-yr period. Twenty-seven patients with confirmed hypoparathyroidism, aged 18-70 yr, were randomized to eit...
Original paper
# 1Mishaela R. Rubin(CU: Columbia University)
47
# 2John P. Bilezikian(CU: Columbia University)
117
OBJECTIVE: Hypoparathyroidism is a disorder in which parathyroid hormone is deficient in the circulation due most often to immunological destruction of the parathyroids or to their surgical removal. The objective of this work was to define the abnormalities in skeletal microstructure as well as to establish the potential efficacy of PTH(1-84) replacement in this disorder. SUBJECTS AND METHODS: Standard histomorphometric and µCT analyses were performed on iliac crest bone biopsies obtained from p...
Review paper
# 1Corrado Betterle(UNIPD: University of Padua)
49
# 2Silvia Garelli(UNIPD: University of Padua)
13
Last. Fabio Presotto(Ospedale dell' Angelo)
20
Hypoparathyroidism (HP) is clinically characterized by the presence of hypocalcemia, usually associated with specific signs and symptoms that depend on how severe and chronic the disease becomes. HP is usually caused by surgical removal of all four parathyroids, while other forms are rarer. Autoimmune HP can occur as an isolated disease or as part of an autoimmune polyendocrine syndrome. Here we review what is known about parathyroid gland autoimmunity, focusing on recently-proposed parathyroid ...
Original paper
# 1Régis Goulart Rosa(FGV: Fundação Getulio Vargas)
28
# 2Alcina Juliana Soares Barros(FGV: Fundação Getulio Vargas)
6
Last. Gustavo Vilela Alves(FGV: Fundação Getulio Vargas)
1
Primary hypoparathyroidism is a rare condition caused by parathyroid hormone deficiency and characterized by hypocalcemia. The clinical manifestations of primary hypoparathyroidism include tetany, seizures, paresthesias, dementia, and parkinsonism. Psychiatric manifestations such as mood disorders are unusual and may constitute a major diagnostic challenge, especially if the typical manifestations caused by hypocalcemia are absent. The patient was a 22-year-old Caucasian man with a history of ch...
Review paper
# 1Giovanna Mantovani(UNIMI: University of Milan)
50
# 2Francesca Marta Elli(Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico)
20
Last. Sabrina Corbetta(UNIMI: University of Milan)
36
Hypothyroidism may occur in association with congenital parathyroid disorders determining parathyroid hormone insufficiency, which is characterized by hypocalcemia and concomitant inappropriately low secretion of parathormone (PTH). The association is often due to loss of function of genes common to thyroid and parathyroid glands embryonic development. Hypothyroidism associated with hypoparathyroidism is generally mild and not associated with goiter; moreover, it is usually part of a multisystem...
Original paper
Idiopathic hypoparathyroidism (IHP) is a rare endocrine condition, which is frequently represented by neuropsychiatric disorders. Hence, the misdiagnosis rate of the disease is rather high, especially for neurologists.We reported a case of misdiagnosed, atypical IHP. In addition, the literature on IHP and the misdiagnosis published in China in the past 2 decades has been reviewed and summarized.Blood testing confirmed that parathyroid hormone (PTH) = 0 pg/mL and the final diagnosis was IHP.With ...
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