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Autoimmunity Reviews
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#1Paolo Fagone (University of Catania)H-Index: 25
#2Rosella CiurleoH-Index: 9
Last. Ferdinando Nicoletti (University of Catania)H-Index: 76
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The emergence of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) has posed a serious threat to global health. As no specific therapeutics are yet available to control disease evolution, more in-depth understanding of the pathogenic mechanisms induced by SARS-CoV-2 will help to characterize new targets for the management of COVID-19. The present study identified a specific set of biological pathways altered in primary human lung epithelium upon SARS-CoV-2 infec...
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#1Michael MahlerH-Index: 32
#2Marie Hudson (JGH: Jewish General Hospital)H-Index: 24
Last. Marvin J. Fritzler (U of C: University of Calgary)H-Index: 57
view all 9 authors...
Abstract Systemic sclerosis (SSc) is a rare chronic disease of unknown etiology characterized by vascular abnormalities and fibrosis involving the skin and internal organs, especially the gastrointestinal tract, lung, heart and kidneys. Although the disease was historically stratified according to the extent of skin involvement, more recent approaches place more emphasis on patterns and extent of internal organ involvement. Despite numerous clinical trials in SSc, disease-modifying treatment opt...
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#1Saeed Mohammadian Haftcheshmeh (MUMS: Mashhad University of Medical Sciences)H-Index: 1
#2Amir Abbas Momtazi-Borojeni (MUMS: Mashhad University of Medical Sciences)H-Index: 12
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#1Cesare MazzaroH-Index: 26
#2Luigino Dal Maso (CEU: Cancer Epidemiology Unit)H-Index: 63
Last. Gabriele Pozzato (UniTS: University of Trieste)H-Index: 33
view all 8 authors...
Hepatitis C virus (HCV) infection affects about 70 million people worldwide. HCV is responsible for both hepatitis and extra-hepatic manifestations. Chronic infection has been shown to develop in about 70% of cases and can progress to cirrhosis or hepatocellular carcinoma. Ten percent of HCV patients may develop extra-hepatic manifestations, including mixed cryoglobulinemia (MC) and non-Hodgkin lymphomas. Many studies have demonstrated that, after antiviral therapy, MC can disappear along with H...
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#1Maria InfantinoH-Index: 8
#2Teresa CarboneH-Index: 2
Last. Stefan PlatzgummerH-Index: 9
view all 30 authors...
Abstract The commercial tests currently available as second-level tests to detect ANA sub-specificities are generally used independently from the ANA immunofluorescence (IIF) pattern. The aim of this study was to evaluate the efficacy of the use of a customizable pattern-oriented antigenic panel by immunoblot (IB) using the International Consensus on ANA Patterns (ICAP) classification scheme, in order to introduce a novel and updated autoimmune diagnostic flowchart. 710 sera referred for routine...
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#1B. Terrier (Paris V: Paris Descartes University)H-Index: 3
#2S. HumbertH-Index: 3
Last. François GoupilH-Index: 1
view all 18 authors...
INTRODUCTION Immune checkpoint inhibitors (ICIs) are associated with immune-related adverse events (irAEs). Among them, ICIs-induced systemic sclerosis (SSc) is poorly known. METHODS To better characterize this irAE, our comprehensive approach combined the description of ICIs-induced scleroderma cases, the systematic review of the literature and the analysis of VigiBase, the WHO pharmacovigilance database. RESULTS We identified two cases with underlying limited cutaneous SSc who presented a dram...
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#1Janet Roberts (Dal: Dalhousie University)H-Index: 1
#2Daniel Ennis (UBC: University of British Columbia)
Last. Aurore Fifi-Mah (U of C: University of Calgary)H-Index: 3
view all 12 authors...
Abstract Objective Although immune checkpoint inhibitors (ICI) have revolutionized cancer therapy, their use is associated with immune toxicities referred to as immune-related adverse events (irAE). Here we describe the clinical presentation and management of rheumatic immune-related adverse events (Rh-irAE) in a national multi-center cohort. Methods All patients presenting with Rh-irAE at 9 academic sites across Canada between January 2013 and January 2019 were identified and included in this r...
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#1Philipp Klemm (University of Giessen)H-Index: 1
#2Ulf Müller-Ladner (University of Giessen)H-Index: 56
Last. O. Hudowenz (University of Giessen)H-Index: 1
view all 5 authors...
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#1Yves Allenbach (French Institute of Health and Medical Research)H-Index: 21
#2C. Anquetil (French Institute of Health and Medical Research)H-Index: 1
Last. Michelle Rosenzwajg (University of Paris)H-Index: 29
view all 15 authors...
Abstract Background In addition to restoring anti-tumor immune responses, immune checkpoint inhibitors (ICI) may also induce immune-related adverse events (irAE) that can affect any organ. We aim to determine the spectrum, timing, clinical features, and fatalities of rheumatic and musculoskeletal Immune-related adverse events (RMS-irAE) associated with ICI. Patients Methods We performed an observational, retrospective, pharmacovigilance study using the World Health Organization international pha...
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