Original paper

Can Denosumab be used in combination with Doxorubicin in Osteosarcoma?

Volume: 11, Issue: 28, Pages: 2763 - 2773
Published: Jul 14, 2020
Abstract
Osteosarcoma is an aggressive bone tumor of the pediatric age. It is therefore important to improve conventional therapies (chemotherapy and surgery). Anticancer drugs often cause osteoporosis due to a misbalance of RANK/RANK-L/OPG pathway. Denosumab is a monoclonal antibody with high affinity and specificity to RANK-L, the ligand released by osteoblasts that enhances osteoclasts differentiation and bone resorption. It is used in osteoporosis...
Paper Details
Title
Can Denosumab be used in combination with Doxorubicin in Osteosarcoma?
Published Date
Jul 14, 2020
Journal
Volume
11
Issue
28
Pages
2763 - 2773
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