Original paper
Improved nearest-neighbor parameters for the stability of RNA/DNA hybrids under a physiological condition
Abstract
The stability of Watson–Crick paired RNA/DNA hybrids is important for designing optimal oligonucleotides for ASO (Antisense Oligonucleotide) and CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats)–Cas9 techniques. Previous nearest-neighbour (NN) parameters for predicting hybrid stability in a 1 M NaCl solution, however, may not be applicable for predicting stability at salt concentrations closer to physiological condition (e.g....
Paper Details
Title
Improved nearest-neighbor parameters for the stability of RNA/DNA hybrids under a physiological condition
Published Date
Jul 14, 2020
Journal
Volume
48
Issue
21
Pages
12042 - 12054
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Notes
History