Role of proteinase-activated receptors 1 and 2 in nonsteroidal anti-inflammatory drug enteropathy

The use of nonsteroidal anti-inflammatory drugs (NSAIDs) can promote lower gastrointestinal detrimental effects. Proteinase-activated receptors 1 (PAR1) and PAR2 are involved in the pathophysiology of several digestive disorders. This study examines the contribution of PAR1 and PAR2 in NSAID-induced small intestinal injury, and to investigate the underlying mechanisms. Male Wistar rats (40 weeks old) were treated with indomethacin (1.5 mg/kg...