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Pharmacological Reports
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#1Matteo Fornai (UniPi: University of Pisa)H-Index: 22
#2RocchinaColucci (UNIPD: University of Padua)H-Index: 31
Last. Luca Antonioli (UniPi: University of Pisa)H-Index: 22
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Background The use of nonsteroidal anti-inflammatory drugs (NSAIDs) can promote lower gastrointestinal detrimental effects. Proteinase-activated receptors 1 (PAR1) and PAR2 are involved in the pathophysiology of several digestive disorders. This study examines the contribution of PAR1 and PAR2 in NSAID-induced small intestinal injury, and to investigate the underlying mechanisms. Methods Male Wistar rats (40 weeks old) were treated with indomethacin (1.5 mg/kg BID) for 14 days. Subgroups of anim...
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#1Mariusz Cichoń (Jagiellonian University)H-Index: 26
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#1Asmaa Mohamed Abdel-Aziz (Minia University)H-Index: 3
#2Samah Mohammed Mahmoud Abozaid (Minia University)H-Index: 1
Last. Hanaa Khalaf (Minia University)H-Index: 2
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BACKGROUND Since diabetes mellitus type-1 (DM-1) induces testicular oxidative and inflammatory damage with finally an ultimate male infertility, and as fenofibrate (FEN) plays an important antioxidant and anti-inflammatory role, the aim of the present study was to investigate the effects of FEN on diabetes-induced reproductive damage and clarifying the underlying related mechanisms. METHODS DM-1 was induced in male Wistar rats by a single intraperitoneal injection of streptozotocin (50 mg/kg). F...
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#1Pavel MarešH-Index: 26
#2Eva KudovaH-Index: 8
Last. Hana KubováH-Index: 20
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BACKGROUND Postictal potentiation presented immediately after cortical seizures in immature rats might be due to imbalance between excitation and inhibition. The aim of the present study was to determine whether augmentation of inhibition mediated by GABAA receptors could also suppress the postictal potentiation. METHODS Twelve-day old rats with implanted electrodes were used in our study. Five drugs were tested: the agonist muscimol, the positive modulator midazolam and three neurosteroids affe...
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BACKGROUND Launching polytherapy with two or three antiseizure drugs (ASDs) in patients with epilepsy is still problematic. The choice of ASDs to combine them together is usually based on clinicians' experience and it requires knowledge about mechanisms of action of the studied ASDs and their drug-drug interactions, whose nature may be favorable, neutral or unfavorable. To characterize three-drug interaction among lacosamide (LCM), lamotrigine (LTG) and valproate (VPA), the type I isobolographic...
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#1Dorota Danielak (Poznan University of Medical Sciences)H-Index: 8
#2Michał Romański (Poznan University of Medical Sciences)H-Index: 9
Last. Franciszek K. Główka (Poznan University of Medical Sciences)H-Index: 16
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PURPOSE Efficacy of treosulfan, used in the treatment of marrow disorders, depends on the activity of its monoepoxy-(EBDM) and diepoxy compounds. The study aimed to describe the pharmacokinetics of treosulfan and EBDM in the rat plasma and brain by means of mixed-effects modelling. METHODS The study had a one-animal-per-sample design and included ninty-six 10-week-old Wistar rats of both sexes. Treosulfan and EBDM concentrations in the brain and plasma were measured by an HPLC-MS/MS method. The ...
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#1Grzegorz Burnat (PAN: Polish Academy of Sciences)H-Index: 4
#1Grzegorz Burnat (PAN: Polish Academy of Sciences)H-Index: 18
Last. Andrzej Pilc (PAN: Polish Academy of Sciences)H-Index: 51
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Background The serotonin 5-HT1A receptor (5-HT1AR) and metabotropic glutamate receptor 4 (mGlu4) have been implicated as sites of antipsychotic drug action. 5-HT1AR belongs to the A class of G protein-coupled receptors (GPCRs); mGlu4 is a representative of class C GPCRs. Both receptors preferentially couple with Gi protein to inhibit cAMP formation. The present work aimed to examine the possibility of mGlu4 and 5-HT1A receptor cross-talk, the phenomenon that could serve as a molecular basis of t...
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#1Xi MeiH-Index: 2
#2Lina Zhu (WMU: Weifang Medical University)
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BACKGROUND An increasing number of studies have shown that Alzheimer's disease (AD) is a systemic disease characterized by brain dysfunction. In this study, we aimed to investigate the effects of curcumin on the liver, an important metabolic organ, and on the brain in APPswe/PS1dE9 (APP/PS1) mice, and the interaction between these effects. METHODS Curcumin was administered to 5-month-old APP/PS1 transgenic mice for 7 consecutive days using the intragastric (ig) and intracerebroventricular (icv) ...
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#1Samira Eghbaliferiz (Birjand University of Medical Sciences)H-Index: 1
#2Faegheh Farhadi (MUMS: Mashhad University of Medical Sciences)H-Index: 2
Last. Amirhossein SahebkarH-Index: 68
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Astrocytes are the most abundant glial cells in the central nervous system, and are important players in both brain injury and neurodegenerative disease. Curcumin (1,7-bis[4-hydroxy-3-methoxyphenyl]-1,6-heptadiene-3,5-dione), the major active component of turmeric, belongs to the curcuminoid family that was originally isolated from the plant Curcuma longa. Several studies suggest that curcumin may have a beneficial impact on the brain pathology and aging. These effects are due to curcumin's anti...
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#1Jian-cheng Zhang (Fujian Medical University)H-Index: 1
#2Xiao-ting Xie (Fujian Medical University)
Last. Pengli Zhu (Fujian Medical University)H-Index: 7
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BACKGROUND In this study, we investigated the effect of forskolin (FSK, a selective adenylate cyclase agonist) on the automatic diastolic depolarization of sinus node cells (SNC) with hypoxia/reoxygenation (H/R) injury. METHODS The SNC of the newborn rat was randomly assigned into the control group, the H/R (H/R injury) group, or the H/R + FSK (H/R injury + FSK treatment) group. Patch-clamp was performed to record the action potential and electrophysiological changes. The cellular distribution o...
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