Pharmacological Reports
Papers 3159
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#1Hanna Szaefer (Poznan University of Medical Sciences)H-Index: 15
#2Barbara Licznerska (Poznan University of Medical Sciences)H-Index: 5
Last.Wanda Baer-Dubowska (Poznan University of Medical Sciences)H-Index: 23
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Abstract Background “Orphan” cytochromes are a new group of P450 cytochromes without a fully recognized biological role. The expression of these CYPs in tumors is higher than that in normal tissues, which makes them attractive as chemopreventive and/or therapeutic targets. In this study, we compared the effect of synthetic methoxy stilbenes and resveratrol on the expression of two orphan cytochromes, CYP2S1 and CYP2W1, in breast cancer cells. Methods Breast cancer cells, lines MCF7 and MDA-MB-23...
#1Edyta Możdżeń (PAN: Polish Academy of Sciences)H-Index: 5
#2Izabela Babińska (University of Warmia and Mazury in Olsztyn)
Last.Lucyna Antkiewicz Michaluk (PAN: Polish Academy of Sciences)
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Abstract Background: 1-Methyl-1,2,3,4-tetrahydroisoquinoline (1MeTIQ) demonstrates significant neuroprotective activity. It can interact with agonistic conformation of DA receptors. 1MeTIQ inhibits the formation of 3,4-dihydroxyphenylacetic acid as well as production of free radicals and shifts DA catabolism toward COMT-dependent O-methylation. 1MeTIQ inhibits both MAO-A and B enzymes activity and increases neurotransmitters levels in the brain. It shows significant antidepressant-like effect in...
#1Yasmin Moustafa Ahmed (Nahda University)H-Index: 2
#2Basim Anwar Shehata Messiha (Beni-Suef University)H-Index: 8
Last.Ali Ahmed Abo-Saif (Nahda University)H-Index: 4
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Abstract Background In the current investigation, the effects of the P2Y12 blocker ticagrelor, the sodium/glucose transporter-2-inhibitor empagliflozin, and the selective estrogen receptor modulator tamoxifen were examined against rheumatoid arthritis (RA)/ diabetes mellitus (DM)-co-morbidity-induced defects in vascular reactivity. Methods After model setting, rats were allocated into a normal control, an RA/DM-co-morbidity, and three treatment groups receiving ticagrelor, empagliflozin and tamo...
#1Yuki Uchihara (Keio: Keio University)H-Index: 3
#2Tomoyuki Ohe (Keio: Keio University)H-Index: 16
Last.Megumi Funakoshi-Tago (Keio: Keio University)H-Index: 22
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Abstract Background Inhibitors for signal transducer and activator of transcription 3 (STAT3), Stattic, BP-1-102, and LLL12 significantly induce apoptosis in transformed Ba/F3 cells expressing an oncogenic fusion protein, nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) that induces the activation of STAT3. We found that the antioxidant reagent, N-acetyl cysteine (NAC) prevented the abilities of Stattic and BP-1-102, but not LLL12 to induce apoptosis in transformed cells expressing NPM-ALK, pr...
#1Sarvinoz I. Rustamova (National University of Uzbekistan)
#2Nargiza A. Tsiferova (National University of Uzbekistan)H-Index: 1
Last.Ravshan Z. Sabirov (National University of Uzbekistan)H-Index: 6
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Abstract Background Cell volume regulation and volume-regulated anion channels are critical for cell survival in non-isosmotic conditions, and dysregulation of this system is detrimental. Although genes and proteins underlying this basic cellular machinery were recently identified, the pharmacology remains poorly explored. Methods We examined effects of 16 flavonoids on the regulatory volume decrease (RVD) of thymocytes under hypoosmotic stress assessed by light transmittance and on the activity...
Top fields of study
Diabetes mellitus