Hiding the Elephant in the Room with Experimental Neutrons
Abstract
The unfolding and proteolysis of proteins in the cell is an essential homeostatic process. This labor is performed by the proteasome: a large ∼2 MDa (26S) assembly of AAA+ proteins working in concert. Across prokaryotes, eukaryotes, and archaea, this ring-like particle features a central cavity in which ATP-driven proteolysis occurs, in collaboration with partner proteins that mediate unfolding and substrate entry. X-ray crystallography and...
Paper Details
Title
Hiding the Elephant in the Room with Experimental Neutrons
Published Date
Jul 1, 2020
Journal
Volume
119
Issue
2
Pages
234 - 235
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History