JNK-mediated disruption of bile acid homeostasis promotes intrahepatic cholangiocarcinoma

Significance Obesity is associated with hepatic steatosis and activation of the cJun NH 2 -terminal kinase (JNK) stress-signaling pathway. Studies in mice demonstrate that JNK deficiency in the liver prevents the development of hepatic steatosis. This observation suggests that inhibition of JNK signaling may represent a possible treatment for hepatic steatosis. However, the long-term consequences of JNK inhibition are poorly understood. Here we...