Esterification of 4β-hydroxycholesterol and other oxysterols in human plasma occurs independently of LCAT
Abstract
The acyltransferase LCAT mediates FA esterification of plasma cholesterol. In vitro studies have shown that LCAT also FA-esterifies several oxysterols, but in vivo evidence is lacking. Here, we measured both free and FA-esterified forms of sterols in 206 healthy volunteers and 8 individuals with genetic LCAT deficiency, including familial LCAT deficiency (FLD) and fish-eye disease (FED). In the healthy volunteers, the mean values of the...
Paper Details
Title
Esterification of 4β-hydroxycholesterol and other oxysterols in human plasma occurs independently of LCAT
Published Date
Sep 1, 2020
Journal
Volume
61
Issue
9
Pages
1287 - 1299
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