Original paper

NCX1 represents an ionic Na+ sensing mechanism in macrophages

Volume: 18, Issue: 6, Pages: e3000722 - e3000722
Published: Jun 22, 2020
Abstract
Inflammation and infection can trigger local tissue Na+ accumulation. This Na+-rich environment boosts proinflammatory activation of monocyte/macrophage-like cells (MΦs) and their antimicrobial activity. Enhanced Na+-driven MΦ function requires the osmoprotective transcription factor nuclear factor of activated T cells 5 (NFAT5), which augments nitric oxide (NO) production and contributes to increased autophagy. However, the mechanism of Na+...
Paper Details
Title
NCX1 represents an ionic Na+ sensing mechanism in macrophages
Published Date
Jun 22, 2020
Volume
18
Issue
6
Pages
e3000722 - e3000722
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