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#1Travis J. Wiles (UO: University of Oregon)H-Index: 12
#2Brandon H. Schlomann (UO: University of Oregon)H-Index: 4
Last. Karen Guillemin (CIFAR: Canadian Institute for Advanced Research)H-Index: 35
view all 6 authors...
Some of the densest microbial ecosystems in nature thrive within the intestines of humans and other animals. To protect mucosal tissues and maintain immune tolerance, animal hosts actively sequester bacteria within the intestinal lumen. In response, numerous bacterial pathogens and pathobionts have evolved strategies to subvert spatial restrictions, thereby undermining immune homeostasis. However, in many cases, it is unclear how escaping host spatial control benefits gut bacteria and how change...
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#1Jessika Consuegra (CNRS: Centre national de la recherche scientifique)
#2Theodore Grenier (CNRS: Centre national de la recherche scientifique)H-Index: 1
Last. Federica Calevro (INSA: Institut national des sciences appliquées)
view all 11 authors...
The interplay between nutrition and the microbial communities colonizing the gastrointestinal tract (i.e., gut microbiota) determines juvenile growth trajectory. Nutritional deficiencies trigger developmental delays, and an immature gut microbiota is a hallmark of pathologies related to childhood undernutrition. However, how host-associated bacteria modulate the impact of nutrition on juvenile growth remains elusive. Here, using gnotobiotic Drosophila melanogaster larvae independently associated...
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#1Kristin Weineck (Goethe University Frankfurt)H-Index: 1
#2Francisco García-Rosales (Goethe University Frankfurt)H-Index: 4
Last. Julio C. Hechavarría (Goethe University Frankfurt)H-Index: 10
view all 3 authors...
The ability to vocalize is ubiquitous in vertebrates, but neural networks underlying vocal control remain poorly understood. Here, we performed simultaneous neuronal recordings in the frontal cortex and dorsal striatum (caudate nucleus, CN) during the production of echolocation pulses and communication calls in bats. This approach allowed us to assess the general aspects underlying vocal production in mammals and the unique evolutionary adaptations of bat echolocation. Our data indicate that bef...
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#1Emily S. Savela (California Institute of Technology)H-Index: 1
#2Nathan G. Schoepp (California Institute of Technology)H-Index: 9
Last. Rustem F. Ismagilov (California Institute of Technology)H-Index: 63
view all 7 authors...
Rapid antibiotic susceptibility testing (AST) for Neisseria gonorrhoeae (Ng) is critically needed to counter widespread antibiotic resistance. Detection of nucleic acids in genotypic AST can be rapid, but it has not been successful for β-lactams (the largest antibiotic class used to treat Ng). Rapid phenotypic AST for Ng is challenged by the pathogen’s slow doubling time and the lack of methods to quickly quantify the pathogen’s response to β-lactams. Here, we asked two questions: (1) Is it poss...
1 CitationsSource
#1Nathan G. Schoepp (California Institute of Technology)H-Index: 9
#2Eric J. Liaw (California Institute of Technology)H-Index: 2
Last. Rustem F. Ismagilov (California Institute of Technology)H-Index: 63
view all 6 authors...
The rise in carbapenem-resistant Enterobacteriaceae (CRE) infections has created a global health emergency, underlining the critical need to develop faster diagnostics to treat swiftly and correctly. Although rapid pathogen-identification (ID) tests are being developed, gold-standard antibiotic susceptibility testing (AST) remains unacceptably slow (1–2 d), and innovative approaches for rapid phenotypic ASTs for CREs are urgently needed. Motivated by this need, in this manuscript we tested the h...
1 CitationsSource
#1Linxiang Yin (Boston Children's Hospital)
#2Geoffrey Masuyer (Stockholm University)H-Index: 14
Last. Pål Stenmark (Stockholm University)H-Index: 24
view all 11 authors...
Botulinum neurotoxins (BoNTs) are a family of bacterial toxins with seven major serotypes (BoNT/A–G). The ability of these toxins to target and bind to motor nerve terminals is a key factor determining their potency and efficacy. Among these toxins, BoNT/B is one of the two types approved for medical and cosmetic uses. Besides binding to well-established receptors, an extended loop in the C-terminal receptor-binding domain (HC) of BoNT/B (HC/B) has been proposed to also contribute to toxin bindi...
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#1Inga Kavazović (University of Rijeka)H-Index: 3
#2Hongya Han (University of Bergen)
Last. Niek de VriesH-Index: 26
view all 15 authors...
The memory CD8 T-cell pool must select for clones that bind immunodominant epitopes with high affinity to efficiently counter reinfection. At the same time, it must retain a level of clonal diversity to allow recognition of pathogens with mutated epitopes. How the level of diversity within the memory pool is controlled is unclear, especially in the context of a selective drive for antigen affinity. We find that preservation of clones that bind the activating antigen with low affinity depends on ...
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#1Ivan-Maximiliano Kur (Goethe University Frankfurt)
#2Pierre-Hugues Prouvot (University of Mainz)H-Index: 4
Last. Albrecht Stroh (University of Mainz)H-Index: 11
view all 11 authors...
Communication with the hematopoietic system is a vital component of regulating brain function in health and disease. Traditionally, the major routes considered for this neuroimmune communication are by individual molecules such as cytokines carried by blood, by neural transmission, or, in more severe pathologies, by the entry of peripheral immune cells into the brain. In addition, functional mRNA from peripheral blood can be directly transferred to neurons via extracellular vesicles (EVs), but t...
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#1Haifang Wang (CAS: Chinese Academy of Sciences)
#2Zeyong Yang (SJTU: Shanghai Jiao Tong University)H-Index: 1
Last. Jun Yan (CAS: Chinese Academy of Sciences)
view all 8 authors...
The circadian clock is a cell-autonomous time-keeping mechanism established gradually during embryonic development. Here, we generated a transgenic zebrafish line carrying a destabilized fluorescent protein driven by the promoter of a core clock gene, nr1d1, to report in vivo circadian rhythm at the single-cell level. By time-lapse imaging of this fish line and 3D reconstruction, we observed the sequential initiation of the reporter expression starting at photoreceptors in the pineal gland, then...
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#1Derek M. Nye (PSU: Pennsylvania State University)H-Index: 1
#2Richard M. Albertson (PSU: Pennsylvania State University)H-Index: 2
Last. Melissa M. Rolls (PSU: Pennsylvania State University)H-Index: 27
view all 9 authors...
While many regulators of axon regeneration have been identified, very little is known about mechanisms that allow dendrites to regenerate after injury. Using a Drosophila model of dendrite regeneration, we performed a candidate screen of receptor tyrosine kinases (RTKs) and found a requirement for RTK-like orphan receptor (Ror). We confirmed that Ror was required for regeneration in two different neuron types using RNA interference (RNAi) and mutants. Ror was not required for axon regeneration o...
1 CitationsSource
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