PLOS Biology
Papers 5665
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#1Qing Yu (UW: University of Wisconsin-Madison)H-Index: 10
#2Chunyue Teng (UW: University of Wisconsin-Madison)
Last. Bradley R. Postle (UW: University of Wisconsin-Madison)H-Index: 50
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We used functional magnetic resonance imaging (fMRI) to investigate the neural codes for representing stimulus information held in different states of priority in working memory. Human participants (male and female) performed delayed recall for 2 oriented gratings that could appear in any of several locations. Priority status was manipulated by a retrocue, such that one became the prioritized memory item (PMI) and another the unprioritized memory item (UMI). Using inverted encoding models (IEMs)...
#1Jesús R. Requena (University of Santiago de Compostela)H-Index: 20
The prion protein, PrP, can adopt at least 2 conformations, the overwhelmingly prevalent cellular conformation (PrPC) and the scrapie conformation (PrPSc). PrPC features a globular C-terminal domain containing 3 α-helices and a short β-sheet and a long flexible N-terminal tail whose exact conformation in vivo is not yet known and a metastable subdomain with β-strand propensity has been identified within it. The PrPSc conformation is very rare and has the characteristics of an amyloid. Furthermor...
#1Patrick Neubert (University of Regensburg)H-Index: 6
#2Arne Homann (University of Regensburg)
Last. Valentin Schatz (University of Regensburg)H-Index: 7
view all 26 authors...
Inflammation and infection can trigger local tissue Na+ accumulation. This Na+-rich environment boosts proinflammatory activation of monocyte/macrophage-like cells (MΦs) and their antimicrobial activity. Enhanced Na+-driven MΦ function requires the osmoprotective transcription factor nuclear factor of activated T cells 5 (NFAT5), which augments nitric oxide (NO) production and contributes to increased autophagy. However, the mechanism of Na+ sensing in MΦs remained unclear. High extracellular Na...
Last. Manuel S. Malmierca (University of Salamanca)H-Index: 40
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Dopamine guides behavior and learning through pleasure, according to classic understanding. Dopaminergic neurons are traditionally thought to signal positive or negative prediction errors (PEs) when reward expectations are, respectively, exceeded or not matched. These signed PEs are quite different from the unsigned PEs, which report surprise during sensory processing. But mounting theoretical accounts from the predictive processing framework postulate that dopamine, as a neuromodulator, could p...
#1Manfeng Zhang (CAS: Chinese Academy of Sciences)
#2Huigang Shi (CAS: Chinese Academy of Sciences)H-Index: 1
Last. Yihua Huang (CAS: Chinese Academy of Sciences)H-Index: 15
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Curli play critical roles in biofilm formation, host cell adhesion, and colonization of inert surfaces in many Enterobacteriaceae. In Escherichia coli, curli biogenesis requires 7 curli-specific gene (csg) products—CsgA through G—working in concert. Of them, CsgG and CsgF are 2 outer membrane (OM)-localized components that consists of the core apparatus for secretion and assembly of curli structural subunits, CsgB and CsgA. Here, we report the cryogenic electron microscopy (cryo-EM) structure of...
#1Özge Z. Aydin (Koç University)H-Index: 3
#2Sevket Onur Taflan (Koç University)H-Index: 1
Last. Elif Nur Firat-Karalar (Koç University)H-Index: 10
view all 4 authors...
Centriolar satellites are dynamic, membraneless granules composed of over 200 proteins. They store, modify, and traffic centrosome and primary cilium proteins, and help to regulate both the biogenesis and some functions of centrosomes and cilium. In most cell types, satellites cluster around the perinuclear centrosome, but their integrity and cellular distribution are dynamically remodeled in response to different stimuli, such as cell cycle cues. Dissecting the specific and temporal functions a...
#1Patricia L. Lockwood (University of Oxford)H-Index: 16
#2Kathryn C. O’Nell (University of Oxford)
Last. Matthew A. J. Apps (University of Oxford)H-Index: 20
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Helping a friend move house, donating to charity, volunteering assistance during a crisis. Humans and other species alike regularly undertake prosocial behaviors—actions that benefit others without necessarily helping ourselves. But how does the brain learn what acts are prosocial? Basile and colleagues show that removal of the anterior cingulate cortex (ACC) prevents monkeys from learning what actions are prosocial but does not stop them carrying out previously learned prosocial behaviors. This...
#1Benjamin M. Basile (NIH: National Institutes of Health)H-Index: 13
#2Jamie L. Schafroth (NIH: National Institutes of Health)H-Index: 1
Last. Elisabeth A. Murray (NIH: National Institutes of Health)H-Index: 50
view all 5 authors...
A key feature of most social relationships is that we like seeing good things happen to others. Research has implicated the anterior cingulate cortex (ACC) in attaching value to social outcomes. For example, single neurons in macaque ACC selectively code reward delivery to the self, a partner, both monkeys, or neither monkey. Here, we assessed whether the ACC’s contribution to social cognition is causal by testing rhesus monkeys (Macaca mulatta) on a vicarious reinforcement task before and after...
2 CitationsSource
#1Eva DoleželováH-Index: 1
#2Michaela Kunzová (Sewanee: The University of the South)
Last. Alena Zíková (Sewanee: The University of the South)H-Index: 19
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Mitochondrial metabolic remodeling is a hallmark of the Trypanosoma brucei digenetic life cycle because the insect stage utilizes a cost-effective oxidative phosphorylation (OxPhos) to generate ATP, while bloodstream cells switch to aerobic glycolysis. Due to difficulties in acquiring enough parasites from the tsetse fly vector, the dynamics of the parasite’s metabolic rewiring in the vector have remained obscure. Here, we took advantage of in vitro–induced differentiation to follow changes at t...
#1Alyssa Batista (UCSD: University of California, San Diego)
#2Jeffrey J. Rodvold (UCSD: University of California, San Diego)H-Index: 9
Last. Kristen Jepsen (UCSD: University of California, San Diego)H-Index: 24
view all 12 authors...
In the tumor microenvironment, local immune dysregulation is driven in part by macrophages and dendritic cells that are polarized to a mixed proinflammatory/immune-suppressive phenotype. The unfolded protein response (UPR) is emerging as the possible origin of these events. Here we report that the inositol-requiring enzyme 1 (IRE1α) branch of the UPR is directly involved in the polarization of macrophages in vitro and in vivo, including the up-regulation of interleukin 6 (IL-6), IL-23, Arginase1...
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Molecular biology
Cell biology