CRISPR-assisted detection of RNA–protein interactions in living cells
Abstract
We have developed CRISPR-assisted RNA–protein interaction detection method (CARPID), which leverages CRISPR–CasRx-based RNA targeting and proximity labeling to identify binding proteins of specific long non-coding RNAs (lncRNAs) in the native cellular context. We applied CARPID to the nuclear lncRNA XIST, and it captured a list of known interacting proteins and multiple previously uncharacterized binding proteins. We generalized CARPID to...
Paper Details
Title
CRISPR-assisted detection of RNA–protein interactions in living cells
Published Date
Jun 22, 2020
Journal
Volume
17
Issue
7
Pages
685 - 688
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