Microbiome Transfer Partly Overrides Lack of IL‐1RI Signaling to Alter Hepatic but not Adipose Tissue Phenotype and Lipid Handling following a High‐Fat Diet Challenge

Scope IL‐1RI‐mediated inflammatory signaling alters metabolic tissue responses to dietary challenges (e.g., high‐fat diet [HFD]). Recent work suggests that metabolic phenotype is transferrable between mice in a shared living environment (i.e., co‐housing) due to gut microbiome exchange. The authors examine whether the metabolic phenotype of IL‐1RI −/− mice fed HFD or low‐fat diet (LFD) could be transferred to wild‐type (WT) mice through gut...