Helen M. Roche
University College Dublin
Publications 296
#1Jessica C. Ralston (UCD: University College Dublin)H-Index: 8
#2Helen M. Roche (UCD: University College Dublin)H-Index: 53
Abstract Type 2 diabetes (T2D) is a progressive phenotype triggered by obesity. Although genetic variation affects T2D progression, this alone explains only 15% of disease heritability. This chapter discusses how environmental factors (e.g., diet and lifestyle) influence molecular pathways, interact with genetic susceptibility, and ultimately affect the progression of T2D. Diet–gene interactions in adipose (fat) have a critical role in disease progression. We therefore provide an overview of adi...
#1Jessica C. RalstonH-Index: 8
#2Helen M. RocheH-Index: 53
Scope: Several studies have examined the whole-genome gene expression response in blood cells to high-fat challenges with differing results. The study aims to identify consistently up- or downregulated genes and pathways in response to a high-fat challenge using several integration methods. Methods and results: Three studies measuring the gene expression response to a high-fat challenge in white blood cells are evaluated for common trends using several integration methods. Overlap in differentia...
#1Y.M. LenighanH-Index: 3
#2M. O'ReillyH-Index: 4
Last.Helen M. RocheH-Index: 53
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#1Maria HughesH-Index: 13
#2Y.M. Lenighan (UCD: University College Dublin)H-Index: 3
Last.Helen M. Roche (UCD: University College Dublin)H-Index: 53
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Finding genetic variants that cause functional disruption or regulatory change among the many implicated GWAs variants remains a key challenge to translating the findings from GWAs to therapeutic treatments. Defining the causal mechanisms behind the variants require functional screening experiments that can be complex and costly. Prioritising variants for functional characterisation using techniques that capture important functional and regulatory elements can assist this. The genetic architectu...
3 CitationsSource
#1Claire L. Lyons (UCD: University College Dublin)H-Index: 8
#2Helen M. Roche (UCD: University College Dublin)H-Index: 53
Nutritional status provides metabolic substrates to activate AMP-Activated Protein Kinase (AMPK), the energy sensor that regulates metabolism. Recent evidence has demonstrated that AMPK has wider functions with respect to regulating immune cell metabolism and function. One such example is the regulatory role that AMPK has on NLRP3-inlflammasome and IL-1β biology. This in turn can result in subsequent negative downstream effects on glucose, lipid and insulin metabolism. Nutrient stress in the for...
4 CitationsSource
#1Aoife M. CurranH-Index: 2
Last.Lorraine BrennanH-Index: 41
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#1M. O'ReillyH-Index: 4
#2Sarina KajaniH-Index: 1
Last.Fiona C. McGillicuddyH-Index: 19
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