Thromboxane A₂ receptors mediate chronic mechanoreflex sensitization in a rat model of simulated peripheral artery disease

We demonstrate that thromboxane A 2 receptors, but not endoperoxide 4 receptors, on the sensory endings of thin fiber muscle afferents contribute to the chronic sensitization of the muscle mechanoreflex in rats with a ligated femoral artery (a model of simulated peripheral artery disease). The data may have important implications for our understanding of blood pressure control during exercise in patients with peripheral artery...