Role of ultraviolet mutational signature versus tumor mutation burden in predicting response to immunotherapy
Abstract
Hydrophobic neoantigens are more immunogenic because they are better presented by the major histocompatibility complex and better recognized by T cells. Tumor cells can evade the immune response by expressing checkpoints such as programmed death ligand 1. Checkpoint blockade reactivates immune recognition and can be effective in diseases such as melanoma, which harbors a high tumor mutational burden (TMB). Cancers presenting low or intermediate...
Paper Details
Title
Role of ultraviolet mutational signature versus tumor mutation burden in predicting response to immunotherapy
Published Date
Jul 7, 2020
Journal
Volume
14
Issue
8
Pages
1680 - 1694
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