Phosphorylation of ULK1 serine 746 dictates ATG5-independent autophagy
Abstract
There is a type of noncanonical autophagy, which is independent of ATG5 (autophagy related 5), also referred to as alternative autophagy. Both canonical and ATG5-independent alternative autophagy require the initiator ULK1 (unc-51 like kinase 1), but how ULK1 regulates these two types of autophagy differently remains unclear. A recent paper from Torii et al. demonstrates that phosphorylation of ULK1 at Ser746 by RIPK3 (receptor interacting...
Paper Details
Title
Phosphorylation of ULK1 serine 746 dictates ATG5-independent autophagy
Published Date
Jun 16, 2020
Journal
Volume
16
Issue
9
Pages
1557 - 1558
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