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Autophagy
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11.06
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#1Cui-Zan Cai (UM: University of Macau)H-Index: 4
#2Chuanbin Yang (Hong Kong Baptist University)H-Index: 10
Last. Wang Yi-tao (UM: University of Macau)H-Index: 55
view all 16 authors...
NRBF2 is a component of the class III phosphatidylinositol 3-kinase (PtdIns3K) complex. Our previous study has revealed its role in regulating ATG14-associated PtdIns3K activity for autophagosome i...
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#1Xin Wen (UM: University of Michigan)H-Index: 5
#2Daniel J. Klionsky (UM: University of Michigan)H-Index: 113
There is a type of noncanonical autophagy, which is independent of ATG5 (autophagy related 5), also referred to as alternative autophagy. Both canonical and ATG5-independent alternative autophagy require the initiator ULK1 (unc-51 like kinase 1), but how ULK1 regulates these two types of autophagy differently remains unclear. A recent paper from Torii et al. demonstrates that phosphorylation of ULK1 at Ser746 by RIPK3 (receptor interacting serine/threonine kinase 3) is the key difference between...
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#1Yuanyuan Chu (CAS: Chinese Academy of Sciences)
#2Yingjin Kang (ShanghaiTech University)
Last. Yanfen Liu (CAS: Chinese Academy of Sciences)H-Index: 6
view all 7 authors...
Macroautophagy/autophagy is a membrane-mediated intracellular degradation pathway, through which bulky cytoplasmic content is digested in lysosomes. How the autophagy initiation and maturation step...
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#1Casey Garr (High Point University)H-Index: 1
#2Candyce M. Sturgeon (High Point University)
Last. Verónica A. Segarra (High Point University)H-Index: 3
view all 4 authors...
The common view of art and science as polar opposites along the educational spectrum can sometimes mask the degree to which they inform one another. In fact, art can also serve as a way to foster i...
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#1Daniel Peña-Oyarzun (University of Chile)H-Index: 6
#2Marcelo Rodriguez-Peña (University of Chile)H-Index: 2
Last. William Perez (Houston Methodist Hospital)
view all 17 authors...
Macroautophagy/autophagy is an intracellular process involved in the breakdown of macromolecules and organelles. Recent studies have shown that PKD2/PC2/TRPP2 (polycystin 2, transient receptor potential cation channel), a non-selective cation channel permeable to Ca2+ that belongs to the family of transient receptor potential channels, is required for autophagy in multiple cell types by a mechanism that remains unclear. Here, we report that PKD2 forms a protein complex with BECN1 (beclin 1), a k...
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#1Federico Pietrocola (KI: Karolinska Institutet)
#2Francesca Castoldi (University of Paris)
Last. Guido Kroemer (Academy of Medical Sciences, United Kingdom)H-Index: 197
view all 4 authors...
Caloric restriction mimetics (CRMs) are nontoxic macroautophagy/autophagy enhancers that act through the stimulation of cytoplasmic protein deacetylation reactions. Thus far, three functional classes of CRMs have been described: inhibitors of acetyltransferases (such as spermidine), inhibitors of acetyl coenzyme (AcCoA) synthesis (such as hydroxycitrate) and activators of deacetylases/sirtuins (such as resveratrol). Triethylenetetramine (also called trientine, abbreviated TETA) is a synthetic po...
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#1Yuchen Lei (UM: University of Michigan)H-Index: 1
#2Daniel J. Klionsky (UM: University of Michigan)H-Index: 113
A key feature of macroautophagy (hereafter autophagy) is the formation of the phagophore, a double-membrane compartment sequestering cargos and finally maturing into a vesicle termed an autophagosome; however, where these membranes originate from is not clear. In a previous study, researchers from the Rubinsztein lab proposed a model in which the autophagosome can evolve from the RAB11A-positive recycling endosome. In their recent paper, they determine that DNM2 (dynamin 2) functions in scission...
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#1Satoru Torii (Tokyo Medical and Dental University)H-Index: 4
#2Shigeomi Shimizu (Tokyo Medical and Dental University)H-Index: 56
Alternative autophagy is an ATG5 (autophagy related 5)-independent, Golgi membrane-derived form of macroautophagy. ULK1 (unc-51 like kinase 1) is an essential initiator not only for canonical autop...
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#1Takeshi Yamamoto (Osaka University)H-Index: 7
#2Yoshitsugu Takabatake (Osaka University)H-Index: 24
Last. Isao Matsui (Osaka University)H-Index: 21
view all 19 authors...
Recently, we identified a novel mechanism of lipotoxicity in the kidney proximal tubular cells (PTECs); lipid overload stimulates macroautophagy/autophagy for the renovation of plasma and organelle membranes to maintain the integrity of the PTECs. However, this autophagic activation places a burden on the lysosomal system, leading to a downstream suppression of autophagy, which manifests as phospholipid accumulation and inadequate acidification in lysosomes. Here, we investigated whether pharmac...
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#1Jingyue Jia (UNM: University of New Mexico)H-Index: 5
#2Aurore Claude-Taupin (UNM: University of New Mexico)H-Index: 4
Last. Keith A. Lidke (UNM: University of New Mexico)H-Index: 25
view all 15 authors...
Membrane integrity is essential for cellular survival and function. The spectrum of mechanisms protecting cellular and intracellular membranes is not fully known. Our recent work has uncovered a ce...
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Top fields of study
Autophagy
Programmed cell death
Biochemistry
Biology
Cell biology