Omega-3 for the prevention of cardiovascular diseases: meta-analysis and trial-sequential analysis

The effectiveness of omega-3 fatty acids (PUFAs) in cardiovascular diseases (CVD) remains a matter of debate. The aim of this work was to evaluate PUFAs in the reduction of cardiovascular mortality in primary and secondary prevention of CVD to determine if further original studies are needed or the available data can be considered conclusive.A meta-analysis was performed according to a dichotomous endpoint followed by a trial-sequential analysis...