Restoring Herpesvirus Entry Mediator (HVEM) Immune Function in HVEM −/− Mice Rescues Herpes Simplex Virus 1 Latency and Reactivation Independently of Binding to Glycoprotein D
Abstract
The immune modulatory protein herpes virus entry mediator (HVEM) is one of several cellular receptors used by herpes simplex virus 1 (HSV-1) for cell entry. HVEM binds to HSV-1 glycoprotein D (gD) but is not necessary for HSV-1 replication in vitro or in vivo Previously, we showed that although HSV-1 replication was similar in wild-type (WT) control and HVEM-/- mice, HSV-1 does not establish latency or reactivate effectively in mice lacking...
Paper Details
Title
Restoring Herpesvirus Entry Mediator (HVEM) Immune Function in HVEM −/− Mice Rescues Herpes Simplex Virus 1 Latency and Reactivation Independently of Binding to Glycoprotein D
Published Date
Jul 30, 2020
Journal
Volume
94
Issue
16
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