Close‐up: HIV/SIV intasome structures shed new light on integrase inhibitor binding and viral escape mechanisms
Abstract
Integrase strand transfer inhibitors (INSTIs) are important components of drug formulations that are used to treat people living with HIV, and second-generation INSTIs dolutegravir and bictegravir impart high barriers to the development of drug resistance. Reported 10 years ago, X-ray crystal structures of prototype foamy virus (PFV) intasome complexes explained how INSTIs bind integrase to inhibit strand transfer activity and provided initial...
Paper Details
Title
Close‐up: HIV/SIV intasome structures shed new light on integrase inhibitor binding and viral escape mechanisms
Published Date
Jun 22, 2020
Journal
Volume
288
Issue
2
Pages
427 - 433
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