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#1Christian Krintel (UCPH: University of Copenhagen)H-Index: 9
#2Jerzy Dorosz (UCPH: University of Copenhagen)H-Index: 2
Last. Jette S. Kastrup (UCPH: University of Copenhagen)H-Index: 32
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Ionotropic glutamate receptors are ligand-gated ion channels governing neurotransmission in the central nervous system. Three major types of antagonists are known for the AMPA-type receptor GluA2: competitive, non-competitive (i.e. negative allosteric modulators; NAMs) used for treatment of epilepsy, and uncompetitive antagonists. We here report a 4.65 A resolution X-ray structure of GluA2, revealing that four molecules of the competitive antagonist ZK200775 and four molecules of the NAM GYKI536...
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#1Malathi Bheri (DU: University of Delhi)H-Index: 1
#2Swati Mahiwal (DU: University of Delhi)
Last. Girdhar K. Pandey (DU: University of Delhi)H-Index: 25
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Protein phosphorylation is a major reversible post-translational modification of proteins. Protein phosphatases function as 'critical regulators' in signaling networks through dephosphorylation of proteins, which have been phosphorylated by protein kinases. A large understanding of their working has been sourced from animal systems rather than the plant or the prokaryotic systems. The eukaryotic protein phosphatases include phosphoprotein phosphatases (PPP), metallo-dependent protein phosphatase...
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#1Michela Rossini (UNIPD: University of Padua)
#2Paola Pizzo (UNIPD: University of Padua)H-Index: 41
Last. Riccardo Filadi (UNIPD: University of Padua)H-Index: 11
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The strategic importance for cellular organelles of being in contact with each other, exchanging messenger molecules, is nowadays well established. Different inter-organelle crosstalk pathways finely regulate multiple physiological cellular mechanisms and their dysregulation has been found to underlie different pathological conditions. In the last years, a great effort has been made to study such organelle interactions, to understand their functional roles within the cell and the molecules invol...
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#1Sambuddha Sen (OSU: Ohio State University)H-Index: 2
#2Amber L. Hendricks (OSU: Ohio State University)
Last. James A. Cowan (OSU: Ohio State University)H-Index: 32
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Mitochondrial BOLA1 is known to form a [2Fe-2S] cluster-bridged heterodimeric complex with mitochondrial monothiol glutaredoxin GLRX5, however, the function of this heterodimeric complex is unclear. Some reports suggest redundant roles for BOLA1 and a related protein, BOLA3, with both involved in the maturation of [4Fe-4S] clusters in a subset of mitochondrial proteins. However, a later report on the structure of BOLA1-GLRX5 heterodimeric complex demonstrated a buried cluster environment and pre...
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#1Patrick Mullen (UVM: University of Vermont)H-Index: 2
#2Jamie A. Abbott (UVM: University of Vermont)H-Index: 4
Last. Christopher S. Francklyn (UVM: University of Vermont)H-Index: 30
view all 8 authors...
Charcot-Marie-Tooth disease (CMT) encompasses a set of genetically and clinically heterogeneous neuropathies characterized by length dependent dysfunction of the peripheral nervous system. Mutations in over 80 diverse genes are associated with CMT, and aminoacyl-tRNA synthetases (ARS) constitute a large gene family implicated in the disease. Despite considerable efforts to elucidate the mechanistic link between ARS mutations and the CMT phenotype, the molecular basis of the pathology is unknown....
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#1Yuta Homma (Tohoku University)H-Index: 5
#2Shu Hiragi (Tohoku University)
Last. Mitsunori Fukuda (Tohoku University)H-Index: 69
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The Rab family of small GTPases regulates intracellular membrane trafficking by orchestrating the biogenesis, transport, tethering, and fusion of membrane-bound organelles and vesicles. Like other small GTPases, Rabs cycle between two states, an active (GTP-loaded) state and an inactive (GDP-loaded) state, and their cycling is catalyzed by guanine nucleotide exchange factors (GEFs) and GTPase-activating proteins (GAPs). Because an active form of each Rab localizes on a specific organelle (or ves...
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#1Susanne Gerndt (LMU: Ludwig Maximilian University of Munich)
#2Einar K. Krogsaeter (LMU: Ludwig Maximilian University of Munich)H-Index: 1
Last. Christian Grimm (LMU: Ludwig Maximilian University of Munich)H-Index: 21
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Two pore channels (TPCs) have been a hot topic in recent literature. Their involvement in various diseases like viral infections and cancer is of great interest for drug research. Due to their localization in the endo-lysosomal system and the lack of cell permeable activators, complex techniques were required for studying channel functions. Here we review the first published lipophilic small molecule activators of TPCs. In independent high-throughput screens, several new agonists were discovered...
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#1Lisete Galego (NOVA: Universidade Nova de Lisboa)H-Index: 2
#2Susana Barahona (NOVA: Universidade Nova de Lisboa)H-Index: 4
Last. Cecília M. Arraiano (NOVA: Universidade Nova de Lisboa)H-Index: 33
view all 4 authors...
BolA has been characterized as an important transcriptional regulator, which is induced in stationary phase of growth, and in response to several stresses. In E. coli its cellular function is associated with cell wall synthesis and division, morphology, permeability, motility and biofilm formation. Phosphorylation has been widely described as one of the most important events involved in the modulation of the activity of many transcription factors. In the present work, we have demonstrated in viv...
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#1Constance J. Jeffery (UIC: University of Illinois at Chicago)H-Index: 24
As more genome sequences are elucidated there is an increasing need for information about the functions of the millions of proteins they encode. The function of a newly sequenced protein is often estimated by sequence alignment with the sequences of proteins with known functions. However, protein superfamilies can contain members that share significant amino acid sequence and structural homology yet catalyze different reactions or act on different substrates. Some homologous proteins differ by h...
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#1Maryna Löwe (HHU: University of Düsseldorf)
#2Milara Kalacheva (Leibniz Association)
Last. Alexej Kedrov (HHU: University of Düsseldorf)H-Index: 1
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Proteins are essential and abundant components of cellular membranes. Being densely packed within the limited surface area, proteins fulfill essential tasks for life, which include transport, signaling, and maintenance of cellular homeostasis. The high protein density promotes non-specific interactions, which affect the dynamics of the membrane-associated processes, but also contribute to higher levels of membrane organization. Here, we provide a comprehensive summary of the most recent findings...
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