Crystal structure and ligand-induced folding of the SAM/SAH riboswitch
Abstract
While most SAM riboswitches strongly discriminate between SAM and SAH, the SAM/SAH riboswitch responds to both ligands with similar apparent affinities. We have determined crystal structures of the SAM/SAH riboswitch bound to SAH, SAM and other variant ligands at high resolution. The riboswitch forms an H-type pseudoknot structure with coaxial alignment of the stem–loop helix (P1) and the pseudoknot helix (PK). An additional three base pairs...
Paper Details
Title
Crystal structure and ligand-induced folding of the SAM/SAH riboswitch
Published Date
Jun 10, 2020
Journal
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