Original paper
Structural Basis for the Activation and Target Site Specificity of CDC7 Kinase
Abstract
CDC7 is an essential Ser/Thr kinase that acts upon the replicative helicase throughout the S phase of the cell cycle and is activated by DBF4. Here, we present crystal structures of a highly active human CDC7-DBF4 construct. The structures reveal a zinc-finger domain at the end of the kinase insert 2 that pins the CDC7 activation loop to motif M of DBF4 and the C lobe of CDC7. These interactions lead to ordering of the substrate-binding platform...
Paper Details
Title
Structural Basis for the Activation and Target Site Specificity of CDC7 Kinase
Published Date
Aug 1, 2020
Journal
Volume
28
Issue
8
Pages
954 - 962.e4
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Notes
History