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#1Kyungjin Min (UPR-RP: UPRRP College of Natural Sciences)H-Index: 2
#2Hye-Jin Yoon (UPR-RP: UPRRP College of Natural Sciences)H-Index: 19
Last. Hyung Ho Lee (UPR-RP: UPRRP College of Natural Sciences)H-Index: 15
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Summary β-Arrestins (βarrs) critically regulate G-protein-coupled receptor (GPCR) signaling and trafficking. βarrs have two isoforms, βarr1 and βarr2. Receptor phosphorylation is a key determinant for the binding of βarrs, and understanding the intricate details of receptor-βarr interaction is the next frontier in GPCR structural biology. The high-resolution structure of active βarr1 in complex with a phosphopeptide derived from GPCR has been revealed, but that of βarr2 remains elusive. Here, we...
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#1Saikat Chakraborty (MPG: Max Planck Society)H-Index: 2
#2Julia Mahamid (MPG: Max Planck Society)H-Index: 19
Last. Wolfgang Baumeister (MPG: Max Planck Society)H-Index: 97
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Summary Microtubules (MTs) are the most rigid elements of the cytoskeleton with in vitro persistence lengths (Lp) in the range of 1–6 mm. In cellular environments, however, MTs often appear strongly curved. This has been attributed to the forces acting upon them in situ where they are embedded in composite networks of different cytoskeletal elements. Hitherto, the nanoscale organization of these networks has remained largely uncharacterized. Cryo-electron tomography (cryo-ET) allowed to visualiz...
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#1Kristof Grohe (LMU: Ludwig Maximilian University of Munich)H-Index: 3
#2Snehal Patel (RUB: Ruhr University Bochum)
Last. Lars V. Schäfer (RUB: Ruhr University Bochum)H-Index: 22
view all 11 authors...
Summary Proteins depend on defined molecular plasticity for their functionality. How to comprehensively capture dynamics correctly is of ubiquitous biological importance. Approaches commonly used to probe protein dynamics include model-free elucidation of site-specific motion by NMR relaxation, molecular dynamics (MD)-based approaches, and capturing the substates within a dynamic ensemble by recent eNOE-based multiple-structure approaches. Even though MD is sometimes combined with ensemble-avera...
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#1Andrew M. Watkins (Stanford University)H-Index: 10
#2Ramya Rangan (Stanford University)H-Index: 3
Last. Rhiju Das (Stanford University)H-Index: 47
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Summary Predicting RNA three-dimensional structures from sequence could accelerate understanding of the growing number of RNA molecules being discovered across biology. Rosetta's Fragment Assembly of RNA with Full-Atom Refinement (FARFAR) has shown promise in community-wide blind RNA-Puzzle trials, but lack of a systematic and automated benchmark has left unclear what limits FARFAR performance. Here, we benchmark FARFAR2, an algorithm integrating RNA-Puzzle-inspired innovations with updated frag...
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#1Matthew Sinnott (UCL: University College London)H-Index: 1
#2Sony Malhotra (Birkbeck, University of London)H-Index: 7
Last. Maya Topf (Birkbeck, University of London)H-Index: 37
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Summary Monolinks are produced in a chemical crosslinking mass spectrometry experiment and are more abundant than crosslinks. They convey residue exposure information, but so far have not been used in the modeling of protein structures. Here, we present the Monolink Depth Score (MoDS), for assessing structural models based on the depth of monolinked residues, corresponding to their distance to the nearest bulk water. Using simulated and reprocessed experimental data from the Proteomic Identifica...
1 CitationsSource
#1Samual D. Dick (Francis Crick Institute)
#2Stefania Federico (Francis Crick Institute)H-Index: 2
Last. Peter Cherepanov (Imperial College London)H-Index: 37
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Summary CDC7 is an essential Ser/Thr kinase that acts upon the replicative helicase throughout the S phase of the cell cycle and is activated by DBF4. Here, we present crystal structures of a highly active human CDC7-DBF4 construct. The structures reveal a zinc-finger domain at the end of the kinase insert 2 that pins the CDC7 activation loop to motif M of DBF4 and the C lobe of CDC7. These interactions lead to ordering of the substrate-binding platform and full opening of the kinase active site...
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#1Kang Zhou (UCLA: University of California, Los Angeles)H-Index: 1
#2Shiheng Liu (UCLA: University of California, Los Angeles)H-Index: 5
Last. Z. Hong Zhou (UCLA: University of California, Los Angeles)H-Index: 48
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Summary Pathogenesis of anthrax disease involves two cytotoxic enzymes—edema factor (EF) and lethal factor (LF)—which are individually recruited by the protective antigen heptamer (PA7) or octamer (PA8) prechannel and subsequently translocated across channels formed on the endosomal membrane upon exposure to low pH. Here, we report the atomic structures of PA8 prechannel-bound full-length EF and LF. In this pretranslocation state, the N-terminal segment of both factors refolds into an α helix en...
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Summary The TSC complex is the cognate GTPase-activating protein (GAP) for the small GTPase Rheb and a crucial regulator of the mechanistic target of rapamycin complex 1 (mTORC1). Mutations in the TSC1 and TSC2 subunits of the complex cause tuberous sclerosis complex (TSC). We present the crystal structure of the catalytic asparagine-thumb GAP domain of TSC2. A model of the TSC2-Rheb complex and molecular dynamics simulations suggest that TSC2 Asn1643 and Rheb Tyr35 are key active site residues,...
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#1Michelle L.D. Snyder (TU: Towson University)H-Index: 3
#2Greg A. Snyder (UMB: University of Maryland, Baltimore)H-Index: 13
An organism’s ability to recognize and respond quickly and appropriately to pathogenic stimuli is a fundamental aspect of innate immunity. Harnessing the dynamic nature of fluorescent microscopy and the resolution of cryo-electron microscopy, Moncrieffe et al. (2020) characterize MyD88-only filaments and provide insight into the mechanisms underlying innate immune signaling.
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#1Marc A. Dämgen (University of Oxford)H-Index: 3
#2Afroditi Maria Zaki (University of Oxford)
Last. Philip C. Biggin (University of Oxford)H-Index: 33
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Recently, we reported the simulation of a stable open state of the glycine receptor. Central to the stability of the simulations was the behavior of the highly conserved leucine residues at the 9′ gate, which were found to rotate into adjacent pockets, thus providing a structural rationale for decades of biochemical observations. In contrast, a previously reported model from Cerdan et al. (2018) resembled a more collapsed state. However, in support of their model, they draw attention to the agre...
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