Review paper
Phase and context shape the function of composite oncogenic mutations
Abstract
Cancers develop as a result of driver mutations1,2 that lead to clonal outgrowth and the evolution of disease3,4. The discovery and functional characterization of individual driver mutations are central aims of cancer research, and have elucidated myriad phenotypes5 and therapeutic vulnerabilities6. However, the serial genetic evolution of mutant cancer genes7,8 and the allelic context in which they arise is poorly understood in both common and...
Paper Details
Title
Phase and context shape the function of composite oncogenic mutations
Published Date
May 27, 2020
Journal
Volume
582
Issue
7810
Pages
100 - 103
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