Original paper
Epigenetic deregulation of lamina-associated domains in Hutchinson-Gilford progeria syndrome
Abstract
Background Hutchinson-Gilford progeria syndrome (HGPS) is a progeroid disease characterized by the early onset of age-related phenotypes including arthritis, loss of body fat and hair, and atherosclerosis. Cells from affected individuals express a mutant version of the nuclear envelope protein lamin A (termed progerin) and have previously been shown to exhibit prominent histone modification changes. Methods Here, we analyze the possibility that...
Paper Details
Title
Epigenetic deregulation of lamina-associated domains in Hutchinson-Gilford progeria syndrome
Published Date
May 25, 2020
Journal
Volume
12
Issue
1
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Notes
History