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Felix Bormann
German Cancer Research Center
Molecular biologyDNA methylationMethylationEpigeneticsBiology
21Publications
6H-index
111Citations
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Publications 14
Newest
#1Tincy Simon (Charité)
#2Soulafa Mamlouk (Charité)H-Index: 3
Last. Slim Khouja (Charité)
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Pancreatic Neuroendocrine Neoplasms (PanNENs) comprise a rare and heterogeneous group of tumors derived from neuroendocrine cells of the pancreas. Despite genetic and epigenetic characterization, biomarkers for improved patient stratification and personalized therapy are sparse and targeted therapies, including the mTOR inhibitor Everolimus, have shown limited success. To better define PanNENs tumors we performed multi-omic analyses on 59 tumors with varying grades (NET G1, NET G2, NET G3 and NE...
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#1Florian Köhler (DKFZ: German Cancer Research Center)H-Index: 3
#2Felix Bormann (DKFZ: German Cancer Research Center)H-Index: 6
Last. Manuel Rodríguez-Paredes (DKFZ: German Cancer Research Center)H-Index: 12
view all 10 authors...
Hutchinson-Gilford progeria syndrome (HGPS) is a progeroid disease characterized by the early onset of age-related phenotypes including arthritis, loss of body fat and hair, and atherosclerosis. Cells from affected individuals express a mutant version of the nuclear envelope protein lamin A (termed progerin) and have previously been shown to exhibit prominent histone modification changes. Here, we analyze the possibility that epigenetic deregulation of lamina-associated domains (LADs) is involve...
1 CitationsSource
#1Felix Bormann (DKFZ: German Cancer Research Center)H-Index: 6
#2Francesca Tuorto (DKFZ: German Cancer Research Center)H-Index: 25
Last. Carine Legrand (DKFZ: German Cancer Research Center)H-Index: 4
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Abstract RNA cytosine-5 methylation (m5C) has emerged as a key epitranscriptomic mark, which fulfills multiple roles in structural modulation, stress signaling and the regulation of protein translation. Bisulfite sequencing is currently the most accurate and reliable method to detect m5C marks at nucleotide resolution. Targeted bisulfite sequencing allows m5C detection at single base resolution, by combining the use of tailored primers with bisulfite treatment. A number of computational tools cu...
1 CitationsSource
#1Florian Koehler (DKFZ: German Cancer Research Center)H-Index: 1
#2Felix Bormann (DKFZ: German Cancer Research Center)H-Index: 6
Last. Manuel Rodríguez-Paredes (DKFZ: German Cancer Research Center)H-Index: 12
view all 7 authors...
Hutchinson-Gilford Progeria Syndrome (HGPS) is a progeroid disease characterized by the early onset of some classically age-related phenotypes including arthritis, loss of body fat and hair and atherosclerosis. Cells from affected individuals express a mutant version of the nuclear envelope protein Lamin A (termed Progerin) and have previously been shown to exhibit prominent chromatin changes. Here, we identify epigenetic deregulation of lamina-associated domains (LADs) as a central feature in t...
1 CitationsSource
#1Kalliopi Pervolaraki (DKFZ: German Cancer Research Center)H-Index: 2
#2Soheil Rastgou Talemi (DKFZ: German Cancer Research Center)H-Index: 1
Last. Steeve Boulant (DKFZ: German Cancer Research Center)H-Index: 29
view all 11 authors...
It is currently believed that type I and III interferons (IFNs) have redundant functions. However, the preferential distribution of type III IFN receptor on epithelial cells suggests functional differences at epithelial surfaces. Here, using human intestinal epithelial cells we could show that although both type I and type III IFNs confer an antiviral state to the cells, they do so with distinct kinetics. Type I IFN signaling is characterized by an acute strong induction of interferon stimulated...
11 CitationsSource
#1Stefanie Geyh (HHU: University of Düsseldorf)H-Index: 8
#2Manuel Rodríguez-Paredes (HHU: University of Düsseldorf)H-Index: 1
Last. Thomas Schroeder (HHU: University of Düsseldorf)H-Index: 23
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Mesenchymal stromal cells are involved in the pathogenesis of myelodysplastic syndromes and acute myeloid leukemia, but the underlying mechanisms are incompletely understood. To further characterize the pathological phenotype we performed RNA sequencing of mesenchymal stromal cells from patients with myelodysplastic syndromes and acute myeloid leukemia and found a specific molecular signature of genes commonly deregulated in these disorders. Pathway analysis showed a strong enrichment of genes r...
4 CitationsSource
#1Felix BormannH-Index: 6
Last. Frank LykoH-Index: 8
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#2Felix BormannH-Index: 6
Last. Frank LykoH-Index: 8
view all 16 authors...
Source
#1Felix Bormann (DKFZ: German Cancer Research Center)H-Index: 6
#2Manuel Rodríguez-Paredes (DKFZ: German Cancer Research Center)H-Index: 12
Last. Frank Lyko (DKFZ: German Cancer Research Center)H-Index: 52
view all 12 authors...
Summary Colorectal adenomas are precursor lesions of colorectal cancers and represent clonal amplifications of single cells from colonic crypts. DNA methylation patterns specify cell-type identity during cellular differentiation and, therefore, provide opportunities for the molecular analysis of tumors. We have now analyzed DNA methylation patterns in colorectal adenomas and identified three biologically defined subclasses that describe different intestinal crypt differentiation stages. Importan...
6 CitationsSource
#1Manuel Rodríguez-Paredes (DKFZ: German Cancer Research Center)H-Index: 12
#2Felix Bormann (DKFZ: German Cancer Research Center)H-Index: 6
Last. Frank LykoH-Index: 52
view all 20 authors...
Cutaneous squamous cell carcinoma (cSCC) is the second most common skin cancer and usually progresses from a UV-induced precancerous lesion termed actinic keratosis (AK). Despite various efforts to characterize these lesions molecularly, the etiology of AK and its progression to cSCC remain partially understood. Here, we use Infinium MethylationEPIC BeadChips to interrogate the DNA methylation status in healthy, AK and cSCC epidermis samples. Importantly, we show that AK methylation patterns alr...
11 CitationsSource
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