Limitations of Contemporary Guidelines for Managing Patients at High Genetic Risk of Coronary Artery Disease

Polygenic risk scores (PRS) for coronary artery disease (CAD) identify high-risk individuals more likely to benefit from primary prevention statin therapy. Whether polygenic CAD risk is captured by conventional paradigms for assessing clinical cardiovascular risk remains unclear. This study sought to intersect polygenic risk with guideline-based recommendations and management patterns for CAD primary prevention. A genome-wide CAD PRS was applied...