Original paper
Randomized phase 2 trial and open-label extension of domagrozumab in Duchenne muscular dystrophy
Abstract
We report results from a phase 2, randomized, double-blind, 2-period trial (48 weeks each) of domagrozumab and its open-label extension in patients with Duchenne muscular dystrophy (DMD). Of 120 ambulatory boys (aged 6 to <16 years) with DMD, 80 were treated with multiple ascending doses (5, 20, and 40 mg/kg) of domagrozumab and 40 treated with placebo. The primary endpoints were safety and mean change in 4-stair climb (4SC) time at week 49....
Paper Details
Title
Randomized phase 2 trial and open-label extension of domagrozumab in Duchenne muscular dystrophy
Published Date
Jun 1, 2020
Journal
Volume
30
Issue
6
Pages
492 - 502
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Notes
History