Chromatin topology reorganization and transcription repression by PML-RARα in acute promyeloid leukemia
Abstract
Background Acute promyeloid leukemia (APL) is characterized by the oncogenic fusion protein PML-RARα, a major etiological agent in APL. However, the molecular mechanisms underlying the role of PML-RARα in leukemogenesis remain largely unknown. Results Using an inducible system, we comprehensively analyze the 3D genome organization in myeloid cells and its reorganization after PML-RARα induction and perform additional analyses in patient-derived...
Paper Details
Title
Chromatin topology reorganization and transcription repression by PML-RARα in acute promyeloid leukemia
Published Date
May 11, 2020
Journal
Volume
21
Issue
1
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