Hedgehog signaling promotes angiogenesis directly and indirectly in pancreatic cancer
Abstract
The inhibition of Hedgehog (Hh) signaling in pancreatic ductal adenocarcinoma (PDAC) reduces desmoplasia and promotes increased vascularity. In contrast to these findings, the Hh ligand Sonic Hedgehog (SHH) is a potent proangiogenic factor in non-tumor models. The aim of this study was to determine the molecular mechanisms by which SHH affects the tumor stroma and angiogenesis. Mice bearing three different xenografted human PDAC (n = 5/group)...
Paper Details
Title
Hedgehog signaling promotes angiogenesis directly and indirectly in pancreatic cancer
Published Date
May 22, 2020
Journal
Volume
23
Issue
3
Pages
479 - 492
Citation AnalysisPro
You’ll need to upgrade your plan to Pro
Looking to understand the true influence of a researcher’s work across journals & affiliations?
- Scinapse’s Top 10 Citation Journals & Affiliations graph reveals the quality and authenticity of citations received by a paper.
- Discover whether citations have been inflated due to self-citations, or if citations include institutional bias.
Notes
History