Andrew S. Liss
Harvard University
Pancreatic cancerAdenocarcinomaCancer researchMedicineBiology
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Publications 59
#1Dirk Bausch (Harvard University)H-Index: 14
#2Stefan Fritz (Harvard University)H-Index: 20
Last. Andrew S. Liss (Harvard University)H-Index: 15
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INTRODUCTION: The inhibition of Hedgehog (Hh) signaling in pancreatic ductal adenocarcinoma (PDAC) reduces desmoplasia and promotes increased vascularity. In contrast to these findings, the Hh ligand Sonic Hedgehog (SHH) is a potent proangiogenic factor in non-tumor models. The aim of this study was to determine the molecular mechanisms by which SHH affects the tumor stroma and angiogenesis. METHODS: Mice bearing three different xenografted human PDAC (n = 5/group) were treated with neutralizing...
#1William L. Hwang (Harvard University)H-Index: 17
#2Karthik A. Jagadeesh (Broad Institute)H-Index: 6
Last. Clifton Rodrigues (Harvard University)
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#1Joo Kyung ParkH-Index: 24
#1Joo Kyung Park (Harvard University)H-Index: 1
Last. Andrew S. LissH-Index: 15
view all 10 authors...
OBJECTIVES: Pancreatic ductal adenocarcinoma (PDAC) is characterized by early metastatic spread in more than 50% of patients. In this study, we sought to understand the migratory properties of (non)metastatic PDAC cells and determine whether the migration of cancer stem cell (CSC) populations accounts for the aggressive nature of this disease. METHODS: The migratory abilities of primary and metastatic PDAC cell lines were investigated using a microfluidic device and time-lapse photography. The v...
#1Rebecca L. Porter (Harvard University)H-Index: 9
#2Neelima K. C. Magnus (Harvard University)H-Index: 1
Last. David T. Ting (Harvard University)H-Index: 27
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Transcriptional profiling has defined pancreatic ductal adenocarcinoma (PDAC) into distinct subtypes with the majority being classical epithelial (E) or quasi-mesenchymal (QM). Despite clear differences in clinical behavior, growing evidence indicates these subtypes exist on a continuum with features of both subtypes present and suggestive of interconverting cell states. Here, we investigated the impact of different therapies being evaluated in PDAC on the phenotypic spectrum of the E/QM state. ...
2 CitationsSource
#1William L. Hwang (Broad Institute)
#2Karthik A. Jagadeesh (Broad Institute)H-Index: 6
Last. Tyler JacksH-Index: 128
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Objective: Pancreatic ductal adenocarcinoma (PDAC) remains a treatment-refractory disease as existing molecular subtypes are insufficient and do not currently inform clinical decisions. Rare cell types, including those responsible for resistance, are difficult to detect with bulk transcriptomic profiling. Indeed, several previously identified transcriptomic subtypes of PDAC are unintentionally driven by “contaminating” stromal components. Single-cell transcriptomics provides an unprecedented deg...
#1Jelena Grahovac (Harvard University)H-Index: 7
#2Shiwei Han (Harvard University)H-Index: 4
Last. Yves Boucher (Harvard University)H-Index: 61
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Pancreatic ductal adenocarcinoma (PDAC) is highly resistant to chemotherapy, partly due to the presence of a dense-fibrotic stroma and adaptive metabolism. Telmisartan is an angiotensin II type receptor 1 (AT1) antagonist with partial peroxisome proliferator-activated receptor gamma (PPARγ) agonistic activity used for treatment of hypertension. The aim of this study was to determine the effects of telmisartan on the viability of PDAC cells and tumor progression. In panels of 4 murine and 8 human...
#1James B. Kobler (Harvard University)H-Index: 30
#2Monica A. Tynan (Harvard University)
Last. Tannin A. Schmidt (University of Connecticut Health Center)H-Index: 26
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#1Matteo Ligorio (Harvard University)H-Index: 10
#2Srinjoy Sil (Harvard University)H-Index: 5
Last. David T. Ting (Harvard University)H-Index: 27
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Summary Single-cell technologies have described heterogeneity across tissues, but the spatial distribution and forces that drive single-cell phenotypes have not been well defined. Combining single-cell RNA and protein analytics in studying the role of stromal cancer-associated fibroblasts (CAFs) in modulating heterogeneity in pancreatic cancer (pancreatic ductal adenocarcinoma [PDAC]) model systems, we have identified significant single-cell population shifts toward invasive epithelial-to-mesenc...
10 CitationsSource